In the largest study of its kind, researchers at the University of Minnesota and University of Toronto have revealed a complex network of genes that work together. Understanding those genetic connections can help develop new life-saving treatments to combat diseases such as cancer, heart disease, and diabetes.
A recent article in Muscle & Nerve – “The Usefulness of Electrodiagnostic Studies in the Diagnosis and Management of Neuromuscular Disorders” proves the value and importance of electrodiagnostic testing to patient care.
Need stronger timber, better biofuel or new sources of green chemicals? A systems biology model built on decades of NC State research will accelerate progress on engineering trees for specific needs.
A Mayo Clinic study of children who received one or more exposures to anesthesia before the age of 3 has provided valuable information about the potential neurological and behavioral impact of general anesthesia on very young children, according to the International Anesthesia Research Society and the Society for Pediatric Anesthesia.
People with diabetes can expect 15 per cent cost saving and three-fold reduction in hospital admissions with pharmacist-managed care
You can wear an exoskeleton, but it won’t turn you into a superhero. In the journal Applied Ergonomics, researchers report that that a commercially available exoskeleton relieved stress on the arms just as it was supposed to—but it increased stress on the back by more than 50 percent.
Often people think performing in front of others will make them mess up, but a new study led by a Johns Hopkins University neuroscientist found the opposite: being watched can make people do better.
A multidisciplinary team of scientists share recent advancements in innovative in-vitro cancer biology methods for screening drug-like molecules in cancer tissue relevant models in a new report published online ahead-of-print at SLAS Discovery. Entitled "Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening," the report can be accessed for free.
The famous Oxford Dodo died after being shot, according to breakthrough research by Oxford University Museum of Natural History and WMG at the University of Warwick.
• Sixty-four percent of US patients undergoing hemodialysis in 2011 received opioids for pain, which is one of the most common reported symptoms in this patient population. • Opioid use was associated with higher risks of altered mental status, fall, and fracture in a dose-dependent manner, and these risks were present even when patients were not prescribed high opioid doses.
An epidemiological study conducted by researchers at University of California San Diego School of Medicine and Seoul National University suggests that persons deficient in vitamin D may be at much greater risk of developing diabetes. The findings are reported April 19 in PLOS One.
Cancer immune cell therapy has made headlines with astounding successes like saving former U.S. President Jimmy Carter from brain cancer. But immunotherapy has also had many tragic flops. Georgia Tech researchers working to optimize the innovative treatment have implanted a genetic switch that activates T-cells when they are inside of tumors. Remote-control light waves resembling those used in a TV remote combine with gold nanorods to flip the switch.
Scientists have re-created brain neurons of obese patients using "disease in a dish" technology, offering a new method to study the brain's role in obesity and possibly help tailor treatments to specific individuals.
A host of nuclear RNA-binding proteins, when misplaced outside the nucleus, form the harmful clumps seen in several brain disorders, including FTD and ALS. Clumps that form from these disease proteins are composed of sticky fibrils that damage nerve cells.
In this issue, find research on Race and opioids, heroin overdose death undercount, folate during pregnancy, age of sexual initiation and health outcomes
In a groundbreaking paper published today in the journal Cell, investigators at the Cancer Research Institute Beth Israel Deaconess Medical Center (BIDMC) have found dozens of important new genes, both coding and non-coding that impact sensitivity to chemotherapy. In doing so, the scientists developed a novel technique that marries CRISPR technology with big data mining to identify and assign function to non-coding RNAs
After testing more than 200,000 chemical compounds, UT Southwestern’s Simmons Cancer Center researchers have identified 170 chemicals that are potential candidates for development into drug therapies for lung cancer.
Researchers in the Department of Astrophysical and Planetary Science have completed an unprecedented "dissection" of twin galaxies in the final stages of merging.
In recent years, researchers have firmly established that gene mutations appearing for the first time, called de novo mutations, contribute to approximately one-third of cases of autism spectrum disorder. In a new study, a team led by scientists at University of California San Diego School of Medicine have identified a culprit that may explain some of the remaining risk: rare inherited variants in regions of non-coding DNA. The findings are published April 20 in Science.
An international team of scientists have developed a new cell imaging technology combining lattice light sheet microscopy (LLSM) and adaptive optics (AO) to create high-resolution “movies” of cells in their 3D environment that also captures subcellular processes
Scientists have developed a new drug compound that shows promise as a future treatment for Charcot-Marie-Tooth disease, an inherited, often painful neurodegenerative condition that affects nerves in the hands, arms, feet and legs. The researchers used the compound to treat the nerves of mice harboring the genetic defects that cause the disease.
El estudio descubrió que cuando los pacientes se someten al trasplante doble, el hígado tiene un efecto protector sobre el riñón.
Both civilians and military veterans with post-traumatic stress disorder (PTSD) reap long-term benefits from psychotherapies used for short-term treatment, according to a new study from Case Western Reserve University.
Scientists at The Scripps Research Institute have identified a protein, called GPR68, that senses blood flow and tells small blood vessels called arterioles when to dilate.
Engineers at the University of Washington have developed a new HD video streaming method that doesn’t need to be plugged in. Their prototype skips the power-hungry components and has something else, like a smartphone, process the video instead.
Triple-negative breast cancer (TNBC) is an aggressive form of the disease accounting for 12 to 18 percent of breast cancers. It is a scary diagnosis, and even though chemotherapy can be effective as standard-of-care, many patients become resistant to treatment. A team at The University of Texas MD Anderson led a study which may explain how resistance evolves over time, and potentially which patients could benefit from chemotherapy.
Scientists have for the first time found direct causal links between the neurotransmitter dopamine and avoidance – behavior related to pain and fear. Researchers have long known that dopamine plays a key role in driving behavior related to pleasurable goals, such as food, sex and social interaction. In general, increasing dopamine boosts the drive toward these stimuli. But dopamine’s role in allowing organisms to avoid negative events has remained mysterious.
A protein that plays an important role in embryonic development and nervous system wiring in humans appears to have been borrowed from bacteria. In a new study, scientists from the UChicago and Stanford describe the three-dimensional structure of proteins called teneurins for the first time.
A new University of Kansas research effort featured in the current edition of Integrative Biology has resulted in a low-cost, reliable blood test that uses a small plastic chip about the size of a credit card that can deliver the same diagnostic information as a bone biopsy — but using a simple blood draw instead.
A smartphone app designed to promote proper child car seat use among parents proved effective in a study led by researchers at Johns Hopkins Bloomberg School of Public Health.
TAMPA, Fla. – Patients with advanced or metastatic melanoma have been able to live longer cancer-free lives because of several new therapies approved over the last decade, such as BRAF and MEK inhibitors. However, despite the success of these targeted agents, most patients eventually develop drug resistance and their cancer regrows.
Scientists at Christiana Care Health System’s Gene Editing Institute have developed a potentially breakthrough CRISPR gene-editing tool. It could allow researchers to take fragments of DNA extracted from human cells, put them into a test tube, and quickly and precisely engineer multiple changes to the genetic code, according to a new study published today in the CRISPR Journal.
New research documents how chemicals and a certain gene activate an enzyme to increase the risk and severity of RA and bone destruction.
New research from the University of Portsmouth has called for stronger industry legislation in developing countries to help fight business monopolies reducing competition.
New research finds that more men have suboptimal testosterone levels than previously known, and it may be putting these men at risk.
A Dutch-Texan team found that most Houston-area drowning deaths from Hurricane Harvey occurred outside the zones designated by government as being at higher risk of flooding: the 100- and 500-year floodplains. Harvey, one of the costliest storms in US history, hit southeast Texas on 25 August 2017 causing unprecedented flooding and killing dozens. Researchers at Delft University of Technology in the Netherlands and Rice University in Texas published their results today in the European Geosciences Union journal Natural Hazards and Earth System Sciences.
UNLV scientist Kelly Tseng, Ph.D. and her team have found that frog embryos can fully regrow their eyes after injuries, a breakthrough that may lead one day to the ability to orchestrate tissue regeneration in humans.
Interim results of clinical trials by investigators at UCSF Benioff Children’s Hospital Oakland and Ann and Robert H. Lurie Children’s Hospital of Chicago reveal that a majority of the 22 patients in two Phase 1/2 studies followed for two years or longer remained free from transfusions. The results of the trials “Gene Therapy in Patients with Transfusion-Dependentβ-Thalassemia,” are published today in the New England Journal of Medicine (NEJM). The results are from two separate, two-year clinical studies using LentiGlobin® gene therapy to stop or reduce chronic blood transfusions in patients with transfusion-dependent β-thalassemia (TDT).
People who have been diagnosed with a mild concussion, or mild traumatic brain injury, may have a 56 percent increased risk of developing Parkinson’s disease, according to a study published in the April 18, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology.
More than one in five fawns of white-tailed deer – the most economically important big-game mammal in the United States – can contract a malaria parasite, making fawns susceptible to diseases and death, a new study co-authored by a University of Florida researcher shows.
Scientists identified a neural circuit in the hypothalamus as the primary mechanism mediating the hormone leptin’s anti-obesity and anti-diabetes effects and found two mechanisms underlying leptin’s inhibition of appetite. The work in mice advances efforts to treat human obesity and diabetes.
In a qualitative study, researchers focused on Cleveland service providers who shared how foreclosure affects their clients. The research was recently published in The Journal of Contemporary Social Services.
Researchers at UT Southwestern Medical Center have identified a protein that is strongly associated with metastatic breast cancer and that could be a target for future therapies.
An international team focused on HIV cure research spearheaded by The Wistar Institute in collaboration with the University of Pennsylvania and Vall d’Hebron Research Institute (VHIR) in Barcelona, Spain, established that the CD32 molecule is not a preferential biomarker to identify HIV silent reservoirs within the immune system of patients undergoing antiretroviral therapy (ART), as proposed by a recent landmark study.
Researchers at the University of Michigan Rogel Cancer Center designed this new delivery system – a drug hidden in a nanodisc – to increase the number of patients who can be treated successfully with cancer immunotherapy drugs.
Virginia Tech researcher Chang Lu and his team found significant difference in the molecular machinery that turns on and off gene expression between cerebellum and prefrontal cortex of a mouse brain. Their results provide clues to the molecular apparatus that is involved in conscious thinking in brains.
Americans waste nearly a pound of food per person each day, but the exact amount of food we trash differs by how healthy your diet is, new research finds. Annually, food waste corresponds with the use of 30M acres of land (7% of total US cropland) and 4.2 trillion gallons of water. Surprisingly, higher quality diets were associated with higher levels of food waste.
Researchers in the University at Buffalo School of Management have developed a new algorithm that cloud computing service providers can use to establish pricing and allocate resources.
A compound from the body's own immune cells can treat psoriasis in mice and holds promise for other autoimmune diseases such as multiple sclerosis, according to a new study at Washington University School of Medicine in St. Louis.
A Vanderbilt team and their international colleagues characterized for the first time a complex, little-understood cellular receptor type that, when activated, shuts off hunger.
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