In a study published today in the Annals of Internal Medicine, Johns Hopkins Medicine researchers say they believe that, for the first time, there is evidence to show that three doses of vaccine increase antibody levels against SARS-CoV-2 — the virus that causes COVID 19 — more than the standard two-dose regimen for people who have received solid organ transplants.
Nearly half a billion people have diabetes, but only 1 in 10 of those in low- and middle-income countries are getting the kind of care that could make their lives healthier, longer and more productive, according to a new global study of data. Many don’t even know they have the condition.
News release about the follow-up data from the landmark SPRINT study of the effect of high blood pressure on cardiovascular disease have confirmed that aggressive blood pressure management — lowering systolic blood pressure to less than 120 mm Hg -- dramatically reduces the risk of heart disease, stroke, and death from these diseases, as well as death from all causes, compared to lowering systolic blood pressure to less than 140 mm Hg.
A combination of inexpensive oral medications may be able to treat fatigue-inducing anemias caused by chronic diseases and inflammation, a new discovery from the University of Virginia School of Medicine suggests.
In the first clinical trial of nicotinamide mononucleotide (NMN), researchers at Washington University School of Medicine in St. Louis have found that the compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice also has clinically relevant effects in people.
Early treatment with anti-VEGF injections slowed diabetic retinopathy in a clinical study from the DRCR Retina Network (DRCR.net). However, two years into the four-year study its effect on vision was similar to standard treatment, which usually begins at the onset of late disease.
Researchers from Rutgers Cancer Institute of New Jersey previously identified a small protein called Rab1A that regulates amino acid signaling. In a recent study, researchers explored the physiological role of Rab1A in mammals using mice though a technique in which one of an organism's genes is made inoperative, known as genetic knockout.
For people who are overweight or obese and have type 2 diabetes, the first line of treatment is usually lifestyle intervention, including weight loss and increased physical activity. While this approach has cardiovascular benefit for many, it can be detrimental for people who have poor blood sugar control, according to a study conducted by researchers at Wake Forest School of Medicine.
Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study. The findings, published online in PNAS, could offer a new way to treat both Type 1 and Type 2 diabetes in people.
Basic biology finding on thyroid hormone function could lead to new treatments for obesity, diabetes and related disorders
Older adults who are classified as having “prediabetes” due to moderately elevated measures of blood sugar usually don’t go on to develop full-blown diabetes.
DALLAS – Feb. 3, 2021 – Gaining more fat cells is probably not what most people want, although that might be exactly what they need to fight off diabetes and other diseases. How and where the body can add fat cells has remained a mystery – but two new studies from UT Southwestern provide answers on the way this process works.
Women with a history of diabetes during pregnancy (gestational diabetes) are twice as likely by mid-life to develop calcium in heart arteries - a strong predictor of heart disease - even if healthy blood sugar levels were attained many years after pregnancy, according to new research published today in the American Heart Association's flagship journal Circulation.
Drinks with sucrose compared to glucose may cause young adults to produce lower levels of appetite-regulating hormones, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
New study in mice finds that a high-fat diet allows cancer cells to outcompete immune cells for fuel, impairing immune function and accelerating tumor growth. Findings suggest new strategies to target cancer metabolism, improve immunotherapies.
Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine learning algorithm to create human liver organoids with blood and bile handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life.
The COVID-19 pandemic has jumpstarted innovation in health care delivery and allowed for real-world testing of diabetes care models in unprecedented ways, according to a manuscript published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Cedars-Sinai researchers might have solved a mystery surrounding Crohn's disease: Why does fat appear to migrate into patients' small intestines?
Researchers created a system that uses CRISPR in a new way. Rather than acting on the genome to create permanent change, their system briefly suppresses genes specific to adenovirus antibody production, just long enough for the virus to deliver its gene therapy cargo unimpeded.
An artificial pancreas originally developed at the University of Virginia Center for Diabetes Technology safely and effectively manages blood sugar levels in children ages 6 to 13 with type 1 diabetes, a national clinical trial has found.
Getting more sleep, and establishing a regular sleep schedule, is a common recommendation for maintaining and improving health, including for people with Type 1 diabetes. Short sleep patterns may affect how the body uses insulin, and irregular sleep schedules can affect glucose through changes in one's circadian rhythm or biological clock.
Mayo Clinic and collaborators have published a preprint that identifies two main signals of efficacy that can inform future clinical trials on plasma therapy on COVID-19 patients. The data are extracted from the Mayo-led national Expanded Access Program (EAP) for convalescent plasma for the treatment of hospitalized patients with COVID-19.
Up to one-third of physicians reported sending patients for a thyroid ultrasound for reasons not supported by clinical care guidelines, a new study led by University of Michigan Rogel Cancer Center researchers finds. Routine use of ultrasounds to detect cancerous thyroid nodules have led to a significant increase in thyroid cancer cases in recent years, although many are low-risk and unlikely to cause serious harm.
Wake Forest School of Medicine, in partnership with University of North Carolina School of Medicine (UNC), Duke University School of Medicine and North Carolina Agricultural and Technical State University (NC A&T), has been awarded a $5.7 million Diabetes Research Center grant from the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health (NIH).
Researchers at Washington University School of Medicine in St. Louis have used induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes, transformed the stem cells into insulin-producing cells, used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes, and implanted the cells into mice to reverse diabetes in the animals.
Researchers at Washington University School of Medicine in St. Louis and Mayo Clinic in Rochester, Minn., have found — in newborn mice — that a component of breast milk may help protect premature babies from developing life-threatening sepsis.
Researchers at Washington University School of Medicine in St. Louis have identified a way to make radiation therapy for colorectal cancer more effective by inhibiting a protein found in cancer cells in the gut.
Studying eczema, researchers at Washington University School of Medicine in St. Louis have found that boosting the number of natural killer cells in the blood is a possible treatment strategy for the skin condition and also may help with related health problems, such as asthma.
Adults who drank sugary beverages daily had an increased risk of developing abnormal blood cholesterol and triglycerides compared to those who did not, according to new findings from a prospective study by researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.
Although 1 in 7 adults smoke cigarettes the year prior to undergoing weight-loss surgery, nearly all successfully quit at least a month before their operation. However, smoking prevalence steadily climbs to pre-surgery levels within seven years, according to new research.
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• Among patients with kidney failure and atrial fibrillation, Black, Hispanic White, and Asian patients filled prescriptions of stroke-preventive medications less often than non-Hispanic White patients, and they were more likely to experience stroke. • Equalizing the distribution of these medications would prevent 7%–12% of the stroke disparity among racial/ethnic minorities.
Diabetes affects nearly 1 in 10 adults in the U.S., of these millions, more than 90% have Type 2 diabetes. Controlling blood sugar and glycosylated hemoglobin levels ― or HbA1c, which is sometimes referred to as A1C ― is key to diabetes management and necessary to prevent its immediate and long-term complications. However, new Mayo Clinic research shows that diabetes management may be dangerously misaligned.
Mayo Clinic的研究人员发现，活体捐献者的肾脏中有一些用显微镜才能观察到的细微结构特征，从这些结构特征中或许可以预测肾脏在接受者体内移植失败的风险。这一发现发表于在线版的Journal of the American Society of Nephrology《美国肾脏学会期刊》上。
Forscher von Mayo Clinic haben entdeckt, dass subtile Strukturmerkmale in Nieren von lebenden Spendern, die nur mit einem Mikroskop gesehen werden können, auf das Risiko für eine Abstoßung beim Empfänger hindeuten können.
اكتشف الباحثون لدى Mayo Clinic أن سِمات بنيوية دقيقة لا يمكن رؤيتها إلا بالمِجهر في الكُلى المأخوذة من المتبرِّعين قد تُنبئ بخطورة فشل زراعة الكُلى للمُتلقِّين. وقد نُشِرت نتائج الدراسة على الإنترنت في مجلَّة الجمعية الأمريكية لطب الكُلى.
Des chercheurs de Mayo Clinic ont découvert que de subtiles caractéristiques que l’on peut observer uniquement au microscope au niveau de la structure des reins provenant de donneurs vivants, pourraient prédire le risque d'échec des greffes chez les receveurs.
Los investigadores de Mayo Clinic descubrieron que algunas características estructurales sutiles de los riñones de los donantes vivos, las cuales solo es posible ver en el microscopio, pueden predecir el riesgo del fracaso del trasplante en el receptor.
Pesquisadores da Mayo Clinic descobriram que características estruturais sutis nos rins de doadores vivos que só podem ser vistas com um microscópio podem ajudar a prever o risco de transplantes malsucedidos nos receptores. Os achados foram publicados virtualmente no Journal of the American Society of Nephrology (Revista da Sociedade Americana de Nefrologia).
High levels of protein in a patient’s urine shortly after an episode of acute kidney injury is associated with increased risk of kidney disease progression, providing a valuable tool in predicting those at highest risk for future loss of kidney function.
Mayo Clinic researchers have discovered that subtle structural features in kidneys from living donors that can only be seen with a microscope may predict the risk of transplant failure in recipients. The findings are published online in the Journal of the American Society of Nephrology.
A protein newly identified as important in type 1 diabetes can delay onset of the disease in diabetic mice, providing a new target for prevention and treatment in people, according to research led by scientists at the U.S. Department of Energy’s Pacific Northwest National Laboratory and Indiana University School of Medicine.
UT Southwestern researchers find that humans and mice with pancreatitis are deficient in a stress hormone called FGF21.
A new Johns Hopkins Medicine-led study provides the strongest evidence to date that hundreds of deceased donor kidneys, discarded each year after being deemed not suitable under current medical criteria, can be transplanted safely and effectively.
Tiny solutions are being sought for big liver problems by a scientist at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).
Which of the two most common bariatric surgeries – gastric sleeve or gastric bypass – has the highest subsequent risk of additional operations or procedures?
With the help of a $1.7 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, a team of researchers in Wayne State’s College of Engineering will explore ways to address urgent need for a safe and efficient oral delivery technology for insulin to improve the lives of diabetes patients.
Scientists at Wake Forest School of Medicine have identified a dead probiotic that reduces age-related leaky gut in older mice. The study is published in the journal GeroScience.
Study in mice shows the nervous system not only detects the presence of Salmonella in the gut but actively stops the organism from infecting the body Nerves in the gut prevent Salmonella infection by shutting the cellular gates that allow bacteria to invade the intestine and spread beyond it As a second line of defense, gut neurons help avert Salmonella invasion by maintaining the levels of key protective microbes in the gut Findings reveal prominent role for nervous system in infection protection and regulation of immunity
University of Illinois at Chicago researchers will study patients with sleep apnea and chronic kidney disease.
Study based at the Icahn School of Medicine at Mount Sinai and other centers finds new system has safety, efficacy benefits for people with type 1 diabetes
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