Curated News: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

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Newswise: For Transplant Recipients, Third Time May Be the Charm for Better COVID Vaccine Protection
Released: 14-Jun-2021 5:15 PM EDT
For Transplant Recipients, Third Time May Be the Charm for Better COVID Vaccine Protection
Johns Hopkins Medicine

In a study published today in the Annals of Internal Medicine, Johns Hopkins Medicine researchers say they believe that, for the first time, there is evidence to show that three doses of vaccine increase antibody levels against SARS-CoV-2 — the virus that causes COVID 19 — more than the standard two-dose regimen for people who have received solid organ transplants.

20-May-2021 1:50 PM EDT
Vast under-treatment of diabetes seen in global study
Michigan Medicine - University of Michigan

Nearly half a billion people have diabetes, but only 1 in 10 of those in low- and middle-income countries are getting the kind of care that could make their lives healthier, longer and more productive, according to a new global study of data. Many don’t even know they have the condition.

Released: 19-May-2021 6:05 PM EDT
Final results of SPRINT study confirm controlling blood pressure critically important in preventing heart disease and stroke
University Hospitals Cleveland Medical Center

News release about the follow-up data from the landmark SPRINT study of the effect of high blood pressure on cardiovascular disease have confirmed that aggressive blood pressure management — lowering systolic blood pressure to less than 120 mm Hg -- dramatically reduces the risk of heart disease, stroke, and death from these diseases, as well as death from all causes, compared to lowering systolic blood pressure to less than 140 mm Hg.

Released: 26-Apr-2021 9:00 AM EDT
Anemia Discovery Points to More Effective Treatment Approaches
University of Virginia Health System

A combination of inexpensive oral medications may be able to treat fatigue-inducing anemias caused by chronic diseases and inflammation, a new discovery from the University of Virginia School of Medicine suggests.

Newswise: Anti-Aging Compound Improves Muscle Glucose Metabolism in People
20-Apr-2021 3:30 PM EDT
Anti-Aging Compound Improves Muscle Glucose Metabolism in People
Washington University in St. Louis

In the first clinical trial of nicotinamide mononucleotide (NMN), researchers at Washington University School of Medicine in St. Louis have found that the compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice also has clinically relevant effects in people.

Newswise: Preventive treatment reduces diabetic retinopathy complications
26-Mar-2021 12:00 PM EDT
Preventive treatment reduces diabetic retinopathy complications
NIH, National Eye Institute (NEI)

Early treatment with anti-VEGF injections slowed diabetic retinopathy in a clinical study from the DRCR Retina Network (DRCR.net). However, two years into the four-year study its effect on vision was similar to standard treatment, which usually begins at the onset of late disease.

Newswise: Exploring Amino Acids Signaling as Intervention for Diabetes and Pancreatic Cancers
11-Mar-2021 3:55 PM EST
Exploring Amino Acids Signaling as Intervention for Diabetes and Pancreatic Cancers
Rutgers Cancer Institute of New Jersey

Researchers from Rutgers Cancer Institute of New Jersey previously identified a small protein called Rab1A that regulates amino acid signaling. In a recent study, researchers explored the physiological role of Rab1A in mammals using mice though a technique in which one of an organism's genes is made inoperative, known as genetic knockout.

10-Mar-2021 2:05 PM EST
Intensive Lifestyle Intervention Is Beneficial for Most People with Type 2 Diabetes, But Not All
Wake Forest Baptist Health

For people who are overweight or obese and have type 2 diabetes, the first line of treatment is usually lifestyle intervention, including weight loss and increased physical activity. While this approach has cardiovascular benefit for many, it can be detrimental for people who have poor blood sugar control, according to a study conducted by researchers at Wake Forest School of Medicine.

Newswise: Swapping Alpha Cells For Beta Cells to Treat Diabetes
Released: 1-Mar-2021 2:00 PM EST
Swapping Alpha Cells For Beta Cells to Treat Diabetes
UT Southwestern Medical Center

Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes by converting glucagon-producing cells into insulin producers instead, a team led by UT Southwestern reports in a new study. The findings, published online in PNAS, could offer a new way to treat both Type 1 and Type 2 diabetes in people.

16-Feb-2021 12:30 PM EST
Discovery Illuminates How Thyroid Hormone ‘Dims’ Metabolism
Perelman School of Medicine at the University of Pennsylvania

Basic biology finding on thyroid hormone function could lead to new treatments for obesity, diabetes and related disorders

Released: 8-Feb-2021 11:45 AM EST
“Prediabetes” Diagnosis Less Useful in Older Patients
Johns Hopkins Bloomberg School of Public Health

Older adults who are classified as having “prediabetes” due to moderately elevated measures of blood sugar usually don’t go on to develop full-blown diabetes.

Newswise: Two Studies Shed Light on How, Where Body Can Add New Fat Cells
Released: 3-Feb-2021 11:00 AM EST
Two Studies Shed Light on How, Where Body Can Add New Fat Cells
UT Southwestern Medical Center

DALLAS – Feb. 3, 2021 – Gaining more fat cells is probably not what most people want, although that might be exactly what they need to fight off diabetes and other diseases. How and where the body can add fat cells has remained a mystery – but two new studies from UT Southwestern provide answers on the way this process works.

Released: 1-Feb-2021 3:10 PM EST
Diabetes during pregnancy may increase risk of heart disease
American Heart Association (AHA)

Women with a history of diabetes during pregnancy (gestational diabetes) are twice as likely by mid-life to develop calcium in heart arteries - a strong predictor of heart disease - even if healthy blood sugar levels were attained many years after pregnancy, according to new research published today in the American Heart Association's flagship journal Circulation.

7-Dec-2020 9:00 AM EST
Different forms of sugar impact hunger-suppressing hormones in young adults
Endocrine Society

Drinks with sucrose compared to glucose may cause young adults to produce lower levels of appetite-regulating hormones, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

Newswise: Obesity impairs immune cell function, accelerates tumor growth in mice
7-Dec-2020 3:20 PM EST
Obesity impairs immune cell function, accelerates tumor growth in mice
Harvard Medical School

New study in mice finds that a high-fat diet allows cancer cells to outcompete immune cells for fuel, impairing immune function and accelerating tumor growth. Findings suggest new strategies to target cancer metabolism, improve immunotherapies.

Newswise: Synthetic Biology and Machine Learning Speed the Creation of Lab-Grown Livers
1-Dec-2020 11:20 AM EST
Synthetic Biology and Machine Learning Speed the Creation of Lab-Grown Livers
Health Sciences at the University of Pittsburgh

Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine learning algorithm to create human liver organoids with blood and bile handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life.

15-Oct-2020 9:55 AM EDT
COVID-19 pandemic drives innovation in diabetes care
Endocrine Society

The COVID-19 pandemic has jumpstarted innovation in health care delivery and allowed for real-world testing of diabetes care models in unprecedented ways, according to a manuscript published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

Newswise: Medical Mystery: ‘Creeping Fat’ in Crohn’s Patients Linked to Bacteria
Released: 30-Sep-2020 9:05 PM EDT
Medical Mystery: ‘Creeping Fat’ in Crohn’s Patients Linked to Bacteria
Cedars-Sinai

Cedars-Sinai researchers might have solved a mystery surrounding Crohn's disease: Why does fat appear to migrate into patients' small intestines?

Newswise: Editing the Immune Response Could Make Gene Therapy More Effective
31-Aug-2020 11:00 AM EDT
Editing the Immune Response Could Make Gene Therapy More Effective
Health Sciences at the University of Pittsburgh

Researchers created a system that uses CRISPR in a new way. Rather than acting on the genome to create permanent change, their system briefly suppresses genes specific to adenovirus antibody production, just long enough for the virus to deliver its gene therapy cargo unimpeded.

Newswise: UVA-Developed Artificial Pancreas Effective for Children Ages 6-13, Study Finds
Released: 27-Aug-2020 8:30 AM EDT
UVA-Developed Artificial Pancreas Effective for Children Ages 6-13, Study Finds
University of Virginia Health System

An artificial pancreas originally developed at the University of Virginia Center for Diabetes Technology safely and effectively manages blood sugar levels in children ages 6 to 13 with type 1 diabetes, a national clinical trial has found.

Released: 25-Aug-2020 11:35 AM EDT
Sleep and diabetes study receives $3M grant
University of Illinois Chicago

Getting more sleep, and establishing a regular sleep schedule, is a common recommendation for maintaining and improving health, including for people with Type 1 diabetes. Short sleep patterns may affect how the body uses insulin, and irregular sleep schedules can affect glucose through changes in one's circadian rhythm or biological clock.

Released: 14-Aug-2020 11:55 AM EDT
Convalescent Plasma Associated with Reduced COVID-19 Mortality in 35,000-Plus Hospitalized Patients
Mayo Clinic

Mayo Clinic and collaborators have published a preprint that identifies two main signals of efficacy that can inform future clinical trials on plasma therapy on COVID-19 patients. The data are extracted from the Mayo-led national Expanded Access Program (EAP) for convalescent plasma for the treatment of hospitalized patients with COVID-19.

Newswise: Some physicians are ordering thyroid tests for unsupported reasons
Released: 12-Aug-2020 12:10 PM EDT
Some physicians are ordering thyroid tests for unsupported reasons
Michigan Medicine - University of Michigan

Up to one-third of physicians reported sending patients for a thyroid ultrasound for reasons not supported by clinical care guidelines, a new study led by University of Michigan Rogel Cancer Center researchers finds. Routine use of ultrasounds to detect cancerous thyroid nodules have led to a significant increase in thyroid cancer cases in recent years, although many are low-risk and unlikely to cause serious harm.

Released: 27-Apr-2020 11:05 AM EDT
Wake Forest School of Medicine Receives NIH Diabetes Research Center Grant with Partner Institutions
Wake Forest Baptist Health

Wake Forest School of Medicine, in partnership with University of North Carolina School of Medicine (UNC), Duke University School of Medicine and North Carolina Agricultural and Technical State University (NC A&T), has been awarded a $5.7 million Diabetes Research Center grant from the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health (NIH).

Newswise: Diabetes reversed in mice with genetically edited stem cells derived from patients
21-Apr-2020 8:50 AM EDT
Diabetes reversed in mice with genetically edited stem cells derived from patients
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have used induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes, transformed the stem cells into insulin-producing cells, used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes, and implanted the cells into mice to reverse diabetes in the animals.

Newswise: Breast milk may help prevent sepsis in preemies
Released: 16-Mar-2020 3:45 PM EDT
Breast milk may help prevent sepsis in preemies
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis and Mayo Clinic in Rochester, Minn., have found — in newborn mice — that a component of breast milk may help protect premature babies from developing life-threatening sepsis.

Newswise: Radiation therapy for colon cancer works better when specific protein blocked
Released: 3-Mar-2020 11:35 AM EST
Radiation therapy for colon cancer works better when specific protein blocked
Washington University in St. Louis

Researchers at Washington University School of Medicine in St. Louis have identified a way to make radiation therapy for colorectal cancer more effective by inhibiting a protein found in cancer cells in the gut.

Newswise:Video Embedded revving-up-immune-system-may-help-treat-eczema
VIDEO
Released: 26-Feb-2020 12:15 PM EST
Revving up immune system may help treat eczema
Washington University in St. Louis

Studying eczema, researchers at Washington University School of Medicine in St. Louis have found that boosting the number of natural killer cells in the blood is a possible treatment strategy for the skin condition and also may help with related health problems, such as asthma.

Newswise: Sugary drinks a sour choice for adults trying to maintain normal cholesterol levels
24-Feb-2020 7:55 AM EST
Sugary drinks a sour choice for adults trying to maintain normal cholesterol levels
Tufts University

Adults who drank sugary beverages daily had an increased risk of developing abnormal blood cholesterol and triglycerides compared to those who did not, according to new findings from a prospective study by researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

Newswise: For Weight-Loss Surgery Patients Who Quit Smoking, Relapse is Common
18-Feb-2020 12:25 PM EST
For Weight-Loss Surgery Patients Who Quit Smoking, Relapse is Common
Health Sciences at the University of Pittsburgh

Although 1 in 7 adults smoke cigarettes the year prior to undergoing weight-loss surgery, nearly all successfully quit at least a month before their operation. However, smoking prevalence steadily climbs to pre-surgery levels within seven years, according to new research.

14-Feb-2020 12:00 PM EST
Racial/Ethnic Disparities in Stroke-Prevention Among Patients Undergoing Dialysis
American Society of Nephrology (ASN)

• Among patients with kidney failure and atrial fibrillation, Black, Hispanic White, and Asian patients filled prescriptions of stroke-preventive medications less often than non-Hispanic White patients, and they were more likely to experience stroke. • Equalizing the distribution of these medications would prevent 7%–12% of the stroke disparity among racial/ethnic minorities.

17-Feb-2020 6:10 PM EST
The potentially deadly paradox of diabetes management
Mayo Clinic

Diabetes affects nearly 1 in 10 adults in the U.S., of these millions, more than 90% have Type 2 diabetes. Controlling blood sugar and glycosylated hemoglobin levels ― or HbA1c, which is sometimes referred to as A1C ― is key to diabetes management and necessary to prevent its immediate and long-term complications. However, new Mayo Clinic research shows that diabetes management may be dangerously misaligned.

Released: 12-Feb-2020 8:50 AM EST
从捐献肾脏细微的结构特征或可预测移植失败的风险
Mayo Clinic

Mayo Clinic的研究人员发现,活体捐献者的肾脏中有一些用显微镜才能观察到的细微结构特征,从这些结构特征中或许可以预测肾脏在接受者体内移植失败的风险。这一发现发表于在线版的Journal of the American Society of Nephrology《美国肾脏学会期刊》上。

Released: 3-Feb-2020 9:00 AM EST
Subtile Strukturmerkmale in gespendeten Nieren können eventuell das Risiko eines Transplantatversagens vorhersagen
Mayo Clinic

Forscher von Mayo Clinic haben entdeckt, dass subtile Strukturmerkmale in Nieren von lebenden Spendern, die nur mit einem Mikroskop gesehen werden können, auf das Risiko für eine Abstoßung beim Empfänger hindeuten können.

Released: 3-Feb-2020 9:00 AM EST
سِمات بنيوية دقيقة في الكُلى المُتبرَّع بها قد تُنبئ بخطورة فشل زراعة الكُلى
Mayo Clinic

اكتشف الباحثون لدى Mayo Clinic أن سِمات بنيوية دقيقة لا يمكن رؤيتها إلا بالمِجهر في الكُلى المأخوذة من المتبرِّعين قد تُنبئ بخطورة فشل زراعة الكُلى للمُتلقِّين. وقد نُشِرت نتائج الدراسة على الإنترنت في مجلَّة الجمعية الأمريكية لطب الكُلى.

Released: 3-Feb-2020 9:00 AM EST
De subtiles caractéristiques structurelles détectées dans les reins donnés pourraient prédire le risque d'échec des greffes
Mayo Clinic

Des chercheurs de Mayo Clinic ont découvert que de subtiles caractéristiques que l’on peut observer uniquement au microscope au niveau de la structure des reins provenant de donneurs vivants, pourraient prédire le risque d'échec des greffes chez les receveurs.

Released: 3-Feb-2020 8:40 AM EST
Sutiles características estructurales de riñones donados pueden predecir riesgo de fracaso del trasplante
Mayo Clinic

Los investigadores de Mayo Clinic descubrieron que algunas características estructurales sutiles de los riñones de los donantes vivos, las cuales solo es posible ver en el microscopio, pueden predecir el riesgo del fracaso del trasplante en el receptor.

Released: 3-Feb-2020 8:25 AM EST
Características estruturais sutis em rins doados podem prever o risco de transplantes malsucedidos
Mayo Clinic

Pesquisadores da Mayo Clinic descobriram que características estruturais sutis nos rins de doadores vivos que só podem ser vistas com um microscópio podem ajudar a prever o risco de transplantes malsucedidos nos receptores. Os achados foram publicados virtualmente no Journal of the American Society of Nephrology (Revista da Sociedade Americana de Nefrologia).

Released: 28-Jan-2020 3:50 PM EST
Protein levels in urine after acute kidney injury predict future loss of kidney function
Vanderbilt University Medical Center

High levels of protein in a patient’s urine shortly after an episode of acute kidney injury is associated with increased risk of kidney disease progression, providing a valuable tool in predicting those at highest risk for future loss of kidney function.

21-Jan-2020 11:35 AM EST
Subtle structural features in donated kidneys may predict risk of transplant failure
Mayo Clinic

Mayo Clinic researchers have discovered that subtle structural features in kidneys from living donors that can only be seen with a microscope may predict the risk of transplant failure in recipients. The findings are published online in the Journal of the American Society of Nephrology.

Newswise: An Out-of-the-Box Attack on Diabetes
8-Jan-2020 7:35 PM EST
An Out-of-the-Box Attack on Diabetes
Pacific Northwest National Laboratory

A protein newly identified as important in type 1 diabetes can delay onset of the disease in diabetic mice, providing a new target for prevention and treatment in people, according to research led by scientists at the U.S. Department of Energy’s Pacific Northwest National Laboratory and Indiana University School of Medicine.

Newswise: Could pancreatitis be a stress hormone deficiency?
Released: 8-Jan-2020 2:45 PM EST
Could pancreatitis be a stress hormone deficiency?
UT Southwestern Medical Center

UT Southwestern researchers find that humans and mice with pancreatitis are deficient in a stress hormone called FGF21.

Newswise: Less-Than-Perfect Kidneys Can be Successfully Used For Transplants, Study Shows
Released: 8-Jan-2020 11:00 AM EST
Less-Than-Perfect Kidneys Can be Successfully Used For Transplants, Study Shows
Johns Hopkins Medicine

A new Johns Hopkins Medicine-led study provides the strongest evidence to date that hundreds of deceased donor kidneys, discarded each year after being deemed not suitable under current medical criteria, can be transplanted safely and effectively.

Newswise: UTHealth’s Cynthia Ju awarded NIH grants for liver injury research
Released: 20-Dec-2019 10:50 AM EST
UTHealth’s Cynthia Ju awarded NIH grants for liver injury research
University of Texas Health Science Center at Houston

Tiny solutions are being sought for big liver problems by a scientist at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth).

17-Dec-2019 10:55 AM EST
Study Shows Risks for Additional Procedures after Bariatric Surgery
Wake Forest Baptist Health

Which of the two most common bariatric surgeries – gastric sleeve or gastric bypass – has the highest subsequent risk of additional operations or procedures?

Newswise: $1.7 M grant to Wayne State College of Engineering aims to improve oral delivery of insulin
Released: 12-Dec-2019 12:45 PM EST
$1.7 M grant to Wayne State College of Engineering aims to improve oral delivery of insulin
Wayne State University Division of Research

With the help of a $1.7 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, a team of researchers in Wayne State’s College of Engineering will explore ways to address urgent need for a safe and efficient oral delivery technology for insulin to improve the lives of diabetes patients.

Released: 9-Dec-2019 2:40 PM EST
Dead Probiotic Strain Shown to Reduce Harmful, Aging-related Inflammation
Wake Forest Baptist Health

Scientists at Wake Forest School of Medicine have identified a dead probiotic that reduces age-related leaky gut in older mice. The study is published in the journal GeroScience.

Newswise:Video Embedded more-than-a-watchdog
VIDEO
2-Dec-2019 2:45 PM EST
More Than a Watchdog
Harvard Medical School

Study in mice shows the nervous system not only detects the presence of Salmonella in the gut but actively stops the organism from infecting the body Nerves in the gut prevent Salmonella infection by shutting the cellular gates that allow bacteria to invade the intestine and spread beyond it As a second line of defense, gut neurons help avert Salmonella invasion by maintaining the levels of key protective microbes in the gut Findings reveal prominent role for nervous system in infection protection and regulation of immunity

Newswise: $2.9M funds new UIC study on sleep apnea, chronic kidney disease
Released: 3-Dec-2019 12:35 PM EST
$2.9M funds new UIC study on sleep apnea, chronic kidney disease
University of Illinois Chicago

University of Illinois at Chicago researchers will study patients with sleep apnea and chronic kidney disease.

16-Oct-2019 9:00 AM EDT
Artificial Pancreas System Better Controls Blood Glucose Levels than Current Technology
Mount Sinai Health System

Study based at the Icahn School of Medicine at Mount Sinai and other centers finds new system has safety, efficacy benefits for people with type 1 diabetes


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