Neurobiologists have uncovered the mechanisms behind the maintenance and decline of key synapses implicated in Alzheimer’s disease. The findings suggest an alternative approach to addressing such brain disorders.
In a new National Institutes of Health (NIH) initiative, the University of Miami Miller School of Medicine was selected for a nationwide Liver Cirrhosis Network. Researchers in the network’s 10 academic medical centers will share patient data and launch clinical trials of a class of medications that could prevent progression of the disease, which causes irreversible scarring of the liver, and complications such as liver cancer.
Research led by a Wayne State University Department of Mathematics professor is aiding researchers in Wayne State’s Department of Psychiatry and Behavioral Neurosciences in analyzing fMRI data. fMRI is the preeminent class of signals collected from the brain in vivo and is irreplaceable in the study of brain dysfunction in many medical fields, including psychiatry, neurology and pediatrics.
In one of the most comprehensive genome-wide association studies of its kind, Penn researchers have identified 182 genes likely responsible for kidney function — many of which can be targeted with existing drugs — and 88 genes for hypertension.
Penn researchers have discovered that TSLP stimulates the immune system to release lipids through the skin’s oil-producing sebaceous glands in mice.
Wistar announces that the National Institutes of Health granted a five-year, $29.15 million Martin Delaney Collaboratories for HIV Cure Research award to the BEAT-HIV Martin Delaney Collaboratory to advance research towards a cure for HIV-1 Infection by Combination Immunotherapy.
A new study led by University of California, Irvine (UCI) researchers identifies two ways in which APOBEC3A— a vital enzyme that is responsible for genetic changes resulting in a variety of cancers while protecting our cells against viral infection—is controlled.
A Wayne State University School of Medicine researcher has been awarded a $1.93 million, five-year grant by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health to study the impact of maternal immunoglobulin D (IgD) transferred to the fetus during pregnancy and its impact on protecting against food allergies.
UC San Diego researchers develop a method to grow hematopoietic stem cells in culture, with clinical implications for bone marrow transplants and aging research.
Naked RNA molecules are too floppy for high-res 3D imaging, but a system developed at SLAC and Stanford fixes that. It reveals detailed RNA structures from a pond scum critter and COVID-19 virus.
NIH-funded researchers at Carnegie Mellon University have demonstrated the potential of a neuromodulation approach that uses low-intensity ultrasound energy, called transcranial focused ultrasound—or tFUS.
Watching a mother mouse gather her pups into the family’s nest trains other female mice without pups to perform the same parenting task, a new study shows. Furthermore, these observations lead to the production of oxytocin in the brains of virgin female mice, biochemically shaping their maternal behaviors even before they have pups of their own.
Using artificial intelligence (AI), researchers from UT Southwestern have developed a way to accurately predict which skin cancers are highly metastatic. The findings, published as the July cover article of Cell Systems, show the potential for AI-based tools to revolutionize pathology for cancer and a variety of other diseases.
Three years after the National Institutes of Health (NIH) launched its 10-year All of Us Research Program, a regional team led by University of Miami Miller School of Medicine faculty has achieved remarkable success in recruiting members of minority communities including Black and Latino participants.
A Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego clinical trial showed that graphic warning labels on cigarette packaging changes perceptions of smokers to recognize the negative consequences of tobacco and consider quitting.
A study led by researchers from The University of Texas MD Anderson Cancer Center found a significant association between cholesterol-lowering drugs commonly known as statins and survival rates of triple-negative breast cancer patients. Since statins are low in cost, easy to access and produce minimal side effects, this could have an important impact on outcomes for this aggressive disease.
Its powers may not rival Wolverine's, but a regenerative implant engineered by researchers at the University of Nebraska Medical Center and University of Nebraska–Lincoln could help repair bone-deep damage following physical trauma, surgery or osteoporosis.
UC San Diego researchers modify remdesivir, creating oral version that can be taken earlier in COVID-19 diagnoses. In cell and animal studies, revised drug proved effective and safe.
DALLAS – July 30, 2021 – UT Southwestern faculty have discovered what appears to be an Achilles’ heel in ovarian cancers, as well as new biomarkers that could point to which patients are the best candidates for possible new treatments.
A Wayne State University School of Medicine researcher has been awarded a $2.3 million grant by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, to support research in circadian RNA modification in metabolic disease.
In a new study, a multi-disciplinary team of researchers has demonstrated that a metabolic regulatory molecule called Them1 prevents fat burning in cells by blocking access to their fuel source, which may contribute to the development of a new type of obesity treatment.
Two different strategies to discover and perfect pharmaceuticals active against the COVID-19 virus have attracted a half million dollars in research funding to support five institutions, including the Baudry Lab at The University of Alabama in Huntsville (UAH).
Removing a protein that is often overexpressed in a rare and aggressive subtype of leukemia can help to slow the cancer’s development and significantly increase the likelihood of survival, according to a study in mice led by scientists at the UCLA Jonsson Comprehensive Cancer Center.
Using advanced imaging technology, Mayo Clinic scientists have provided an unprecedented understanding of the BRCA1-BARD1 protein complex, which is often mutated in patients with breast or ovarian cancer. Their paper, published in Nature, identifies aspects of how BRCA1-BARD1 functions, supporting future translational research, cancer prevention efforts and drug development.
In a major advancement in the field of gene therapy for rare and devastating diseases, researchers at Children’s Hospital of Philadelphia (CHOP) have developed a “dimmer switch” system that can control levels of proteins expressed from gene therapy vectors. The system is based on alternative RNA splicing using an orally available small molecule and works effectively in tissues throughout the body, including the brain. The first research regarding this innovation was published today in the journal Nature.
In a Journal of the American Medical Association Psychiatry study led by Pearl Chiu and Brooks King-Casas of the Fralin Biomedical Research Institute at VTC, brain imaging and mathematical modeling reveal previously unreported mechanistic features of symptoms associated with major depressive disorder.
A meta-analysis of nearly 200,000 men revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors.
The National Institutes of Health (NIH) is embarking on a massive research project to shed light on early child development, including the health and developmental implications of opioid use during pregnancy. The very first task is to ensure the study — the HEALthy Brain and Child Development study (HBCD) — is on solid legal and ethical ground.
Focus of the work is bolstering B-cell immunity to help body beat bacteria
Researchers at the National Institutes of Health have discovered that decisions based on visual information, which involve a complex stream of data flowing forward and backwards along the brain’s visual pathways, is broadcast widely to neurons in the visual system, including to those that are not being used to make the decision.
Researchers at the National Institutes of Health have discovered that decisions based on visual information, which involve a complex stream of data flowing forward and backwards along the brain’s visual pathways, is broadcast widely to neurons in the visual system, including to those that are not being used to make the decision.
People who are just beginning treatment for high blood pressure can benefit equally from two different classes of medicine - angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) - yet ARBs may be less likely to cause medication side effects, according to an analysis of real-world data published today in Hypertension, an American Heart Association journal.
Researchers have discovered a limitation of the immune system in battles against cancers or viruses: T cells remain programmed to stay exhausted even weeks after exposure to a virus ended. Scientists need to take this "T cell exhaustion” into account when devising immune-based therapies.
Emergency department visit rates because of an opioid overdose increased by 28.5% across the U.S. in 2020, compared to 2018 and 2019, recent Mayo Clinic research finds. Emergency visits overall decreased by 14% last year, while visits because of an opioid overdose increased by 10.5%. The result: Opioid overdoses were responsible for 0.32 out of 100 visits, or 1 in every 313 visits, which is up from 0.25, or 1 in every 400 visits, the previous two years.
A new technology for cellular immunotherapy developed by Abramson Cancer Center researchers at Penn Medicine showed promising anti-tumor activity in the lab against hard-to-treat cancers driven by the once-considered “undruggable” KRAS mutation, including lung, colorectal, and pancreatic.
The University of Miami Miller School of Medicine is helping to lead a National Institutes of Health (NIH) COVID-19 testing initiative to safely return children to in-person school.
The human body is essentially made up of trillions of living cells.
UC San Diego researchers and their colleagues have discovered that spontaneous impulses of dopamine, the neurological messenger known as the brain’s “feel good” chemical, occur in the brain of mice. The study found that mice can willfully manipulate these random dopamine pulses for reward.
The body’s so-called good cholesterol may be even better than we realize. New research from Washington University School of Medicine in St. Louis suggests that one type of high-density lipoprotein (HDL) has a previously unknown role in protecting the liver from injury. This HDL protects the liver by blocking inflammatory signals produced by common gut bacteria.
An expanded collaboration between APL and the Amazon Web Services' Open Data Sponsorship Program will further enable the storage and accessibility of ever-expanding neuroimaging datasets generated by the neuroscience research community.
UC San Diego engineers developed a soft, stretchy ultrasound patch that can be worn on the skin to monitor blood flow through vessels deep inside the body. Such a device can make it easier to detect cardiovascular problems, like blockages in the arteries that could lead to strokes or heart attacks.
The Tulane spin-out BioAesthetics is teaming up with a Tulane biomedical engineering professor to develop a new graft for treating pelvic organ prolapse, which affects millions of women around the world. BioAesthetics, whose CEO and COO are both Tulane graduates, is collaborating with Tulane researcher Kristin Miller, an associate professor of biomedical engineering whose lab will conduct the testing of the graft.
Mount Sinai researchers uncover a potential pathway for treatment that can prevent blindness
A form of gene therapy protects optic nerve cells and preserves vision in mouse models of glaucoma, according to research supported by NIH’s National Eye Institute. The findings suggest a way forward for developing neuroprotective therapies for glaucoma, a leading cause of visual impairment and blindness.
New study of artificial intelligence tools that analyze tumor images shows how they can make inaccurate predictions based on the institution that submitted the image
A new study, led by University of Minnesota Twin Cities engineering researchers, shows that the stiffness of protein fibers in tissues, like collagen, are a key component in controlling the movement of cells. The groundbreaking discovery provides the first proof of a theory from the early 1980s and could have a major impact on fields that study cell movement from regenerative medicine to cancer research.
Tarsha Jones, Ph.D., principal investigator and an assistant professor of nursing at FAU’s Christine E. Lynn College of Nursing, has received the National Institute of Health (NIH) K01 Career Development Award, a five-year, $772,525 award for a project titled, “Decision Support for Multigene Panel Testing and Family Risk Communication among Racially/Ethnically Diverse Young Breast Cancer Survivors.”
UT Southwestern researchers report the first structural confirmation that endogenous – or self-made – molecules can set off innate immunity in mammals via a pair of immune cell proteins called the TLR4−MD-2 receptor complex. The work has wide-ranging implications for finding ways to treat and possibly prevent autoimmune diseases such as multiple sclerosis and antiphospholipid syndrome.
UT Southwestern researchers have identified an immune protein tied to the rare neurodegenerative condition known as Niemann-Pick disease type C. The finding, made in mouse models and published online in Nature, could offer a powerful new therapeutic target for Niemann-Pick disease type C, a condition that was identified more than a century ago but still lacks effective treatments.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right