A collaborative effort between researchers at the Salk Institute for Biological Studies and the University of California, San Diego, successfully used human induced pluripotent stem (iPS) cells derived from patients with Rett syndrome to replicate autism in the lab and study the molecular pathogenesis of the disease.
In an important breakthrough, scientists at McMaster University in Hamilton, ON, Canada, have discovered how to make human blood from adult human skin. Published in Nature, their paper has also shown the conversion of stem cells is direct, without translation through a pluripotent stem cell state.
New research shows how a specific protein controls the body's ability to regulate magnesium. Though it is vital to more than 300 biochemical reaction in the body, the molecular mechanism for controlling magnesium were not previously understood.
A study by researchers at the Salk Institute for Biological Studies revealed that stem cells can sense a decrease in available nutrients and respond by retaining only a small pool of active stem cells for tissue maintenance. When, or if, favorable conditions return, stem cell numbers multiply to accommodate increased demands on the tissue.
Researchers at North Carolina State University have found that the overproduction of a key protein in stem cells causes those stem cells to form cancerous tumors. Their work may lead to new treatments for a variety of cancers.
A team of physicians and scientists from the Cedars-Sinai Regenerative Medicine Institute and Department of Surgery, led by Dan Gazit, DMD, PhD has been awarded a three-year $1.9 million grant from the California stem cell agency to fund research leading to clinical trials for what could become the first biological treatment for the most common type of bone fracture in osteoporosis patients.
The state stem cell agency today awarded grants totaling $10.4 million to three researchers with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA to translate basic science into new and more effective therapies to regenerate bone and treat deadly brain cancers and corneal disorders that result in blindness.
A change in membrane voltage in newly identified "instructor cells" can cause stem cells' descendants to trigger melanoma-like growth in distant pigment cells. This metastatic transformation is due to changes in serotonin transport. Discovery of this novel bioelectric signal and cell type may help fight cancer, vitiligo and birth defects.
Scientists unravel the molecular link between damage-induced inflammation and muscle regeneration.
Biomedical researchers at the University at Buffalo have engineered adult stem cells that scientists can grow continuously in culture, a discovery that could speed development of cost-effective treatments for diseases including heart disease, diabetes, immune disorders and neurodegenerative diseases.
A new approach to anchor teeth back in the jaw using stem cells has been developed and successfully tested in the laboratory for the first time by researchers at the University of Illinois at Chicago.
The report in the June 4 issue of Cell Stem Cell reveals that an enzyme that changes the way DNA is packaged in cells allows specific genes to be turned on and off, thereby preventing a stem cell from becoming another cell type.
Kansas State University has been a issued a patent for a plentiful and noncontroversial source of stem cells from a substance in the umbilical cord. The patent addresses procedures to isolate, culture and bank stem cells found in Wharton's jelly -- the substance that cushions blood vessels in the umbilical cord. These cells are called cord matrix stems cells and are different than those obtained from the blood cells in umbilical cords.
UT Southwestern Medical Center researchers have identified unique metabolic properties that allow a specific type of stem cell in the body to survive and replicate in low-oxygen environments.
Vital progress in stem cell research by hundreds of U.S. laboratories is threatened after last week’s injunction prohibiting federal funding for the study of human embryonic stem cells (hESCs). The president of the International Society for Stem Cell Research (ISSCR), Elaine Fuchs, Rockefeller University, U.S., stated that the setbacks for advancing biomedical research on stem cells and translating this knowledge into new and improved treatments for patients are already considerable, and escalate with each day the injunction continues.
Female induced pluripotent stem (iPS) cells, reprogrammed from human skin cells into cells that have the embryonic-like potential to become any cell in the body, retain an inactive X chromosome, stem cell researchers at UCLA have found.
A long-held assumption about asymmetrical division of stem cells has cracked. Researchers at the University of Oregon report that the mitotic spindle does not act alone -- that cortical proteins help to position a cleavage furrow in the right location.
For the first time, researchers at Fred Hutchinson Cancer Research Center have identified and isolated adult mammary stem cells in mice. Long-term implications of this research may include the use of such cells to regenerate breast tissue, provide a better understanding of the role of adult stem cells in breast cancer development, and develop potential new targets for anti-cancer drugs.
On August 23rd, a federal district judge issued a temporary ban on federal funding for embryonic stem cell research. Stem cell research holds great promise for the treatment of millions of Americans with debilitating and possibly fatal diseases, including diabetes and heart disease. Because of the court injunction, the NIH reports that it will not review grant applications involving stem cell research, and similar grants that are up for renewal will not be funded.
The American Association for Cancer Research (AACR), the world’s oldest and largest cancer research organization, reiterates its support for the responsible conduct of human embryonic stem cell research that, up until this week, was funded by the National Institutes of Health (NIH) and expresses concern that the recent Federal District Court injunction to block federal funding for human embryonic stem cell research is a setback for scientific discovery.
Obama's ruling helped government-funded U.S. researchers by enabling them to use the best possible existing embryonic stem cell lines in conducting their research. The court decision is unfortunate, because it threatens to impede the progress of regenerative medicine in our country.
A study led by a researcher at Albert Einstein College of Medicine of Yeshiva University has revealed a unique “partnership” between two types of bone marrow stem cells, which could lead to advances in regenerative medicine.
Adult stem cells that are vital for airway repair in the lung but that persist in areas where pre-cancerous lesions are found are associated with a poor prognosis in patients who develop cancer, even those with early stage disease, researchers at UCLA’s Jonsson Comprehensive Cancer Center have found.
Mayo Clinic investigators, with Belgian collaborators, have demonstrated that rationally “guided” human adult stem cells can effectively heal, repair and regenerate damaged heart tissue. The findings -- called “landmark work” in an accompanying editorial -- appear in today’s Journal of the American College of Cardiology.
Researchers at the Buck Institute for Age Research have successfully used human induced pluripotent stem cells (iPSCs) to treat rodents afflicted with Parkinson’s Disease (PD). The research validates a scalable protocol that can be used to manufacture the type of neurons needed to treat the disease and paves the way for the use of iPSC’s in various biomedical applications.
Having charted the occurrence of a common chemical change that takes place while stem cells decide their fates and progress from precursor to progeny, a Johns Hopkins-led team of scientists has produced the first-ever epigenetic landscape map for tissue differentiation.
The National Science Foundation has awarded $3 million to Georgia Tech to fund a unique research program on stem cell bio-manufacturing. The program is specifically focused on developing engineering methods for stem cell production, in order to meet the anticipated demand for stem cells.
Human embryonic stem (ES) cells and adult cells reprogrammed to an embryonic stem cell-like state—so-called induced pluripotent stem or iPS cells—exhibit very few differences in their gene expression signatures and are nearly indistinguishable in their chromatin state, according to Whitehead Institute researchers.
Patients with deadly glioblastomas who received high doses of radiation that hit a portion of the brain that harbors neural stem cells had double the progression-free survival time as patients who had lower doses or no radiation targeting the area, a study from the Radiation Oncology Department at UCLA’s Jonsson Comprehensive Cancer Center has found.
New research, published in the journal Development, by Dr. Anthony-Samuel LaMantia, professor of Pharmacology & Physiology and director of the newly formed GW Institute for Neuroscience, and his colleagues have identified the stem cells that generate three critical classes of nerve cells – olfactory receptors (ORNs), vomeronasal (VRNs) and gonadotropin releasing hormone (GnRH) neurons – that are responsible for enabling animals and humans, to eat, interact socially and reproduce.
Scientists at the UCLA Broad Stem Cell Research Center have described a population of cells that mark the very first stage of differentiation of human embryonic stem cells as they enter a developmental pathway that leads to production of blood, heart muscle, blood vessels and bone.
UNC researchers reveal how a protein called Tet1 helps stem cells keep their “stemness” in a paper published in Nature.
With more than 100 billion neurons and billions of other specialized cells, the human brain is a marvel of nature. It is the organ that makes people unique.
Cells from frozen human blood samples can be reprogrammed to an embryonic stem-cell-like state, according to Whitehead Institute researchers. These cells can be multiplied and used to study the genetic and molecular mechanisms of blood disorders and other diseases.
Stem cells in the brain remain dormant until called upon to divide and make more neurons. However, little has been known about the molecular guards that keep them quiet. Now scientists from the Salk Institute for Biological Studies have identified the signal that prevents stem cells from proliferating, protecting the brain against too much cell division and ensuring a pool of neural stem cells that lasts a lifetime.
A new study from researchers in Ottawa and Toronto suggests that a commonly used type of bone marrow stem cell may be able to help treat sepsis, a deadly condition that can occur when an infection spreads throughout the body.
NYU Langone Medical Center has received a $5.4 million shared facility award from the Empire State Stem Cell Board’s New York State Stem Cell Science (NYSTEM) program.
Following stem cell therapy, an adult patient experienced a new and previously unrecognized complication, which required removal of one of the kidneys, according to a case report appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN).
A Florida State University researcher has identified the important role that a key protein plays in cell division, and that discovery could lead to a greater understanding of stem cells.
The International Society for Stem Cell Research (ISSCR) prepares for the opening of the largest international conference specifically for stem cell professionals at the ISSCR 8th Annual Meeting in San Francisco, CA USA.
The International Society for Stem Cell Research (ISSCR) announced today that it has launched “A Closer Look at Stem Cell Treatments“ (www.closerlookatstemcells.org), a Web site to arm patients, their families and doctors with information they need to make decisions about stem cell treatments.
A gene shown to play a role in the aging process appears to play a role in the regulation of the differentiation of embryonic stem cells, according to researchers from the Center for Stem Cell Biology and Regenerative Medicine and the Department of Medicine at Thomas Jefferson University.
A new synthetic Petri dish coating could overcome a major challenge to the advancement of human embryonic stem cell research, say University of Michigan researchers.
A previously unknown pattern in DNA methylation - an event that affects cell function by altering gene expression – has been uncovered for the first time by stem cell researchers at UCLA, a finding that could have implications in preventing some cancers and correcting defects in human stem cell lines.
For two decades, the laboratory mouse has been the workhorse of biomedical studies and the only mammal whose genes scientists could effectively and reliably manipulate to study human diseases and conditions.
Rensselear Polytechnic Institute to expand stem cell research capabilities with $2.45 million New York State Stem Cell Science program grant to outfit laboratories in the Center for Biotechnology and Interdisciplinary Studies.
Leading stem cell and vascular biology researcher Paul S. Frenette, M.D., has been named the first director of the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Albert Einstein College of Medicine of Yeshiva University. Dr. Frenette will spearhead Einstein’s efforts to build upon existing resources to create a premier stem cell research institute.
A technique pioneered in the Tissue Engineering and Regenerative Medicine Laboratory of Dr. Jeremy Mao, the Edward V. Zegarelli Professor of Dental Medicine at Columbia University Medical Center, can orchestrate stem cells to migrate to a three-dimensional scaffold infused with growth factor, holding the translational potential to yield an anatomically correct tooth in as soon as nine weeks once implanted.
Human stem cells administered intravenously can restore alveolar epithelial tissue to a normal function in a novel ex vivo perfused human lung after E. coli endotoxin-induced acute lung injury (ALI), according to research from the University of California San Francisco.
According to Whitehead Institute researchers, oxygen levels in the lab can permanently alter human embryonic stem (ES) cells, inducing X chromosome inactivation in female cells. This indicates that the current methods of isolation and maintenance are suboptimal.
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