Curated News: National Institutes of Health (NIH)

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What gives one friend influence over another? Considerable attention has focused on who influences whom; much less is known about why one partner is prone to be influenced by the other. A study tested the hypothesis that within a friend dyad, having fewer friends than one’s partner increases susceptibility to influence, because it reduces dissimilarity and promotes compatibility. Results showed that partners with fewer friends were influenced by children with more friends. In each case, the partner with fewer friends became more similar to the partner with more friends. Academic engagement was the only domain where partners with fewer friends also influenced partners with more friends.

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Mulheres com câncer em uma das mamas podem ter um risco mais elevado de desenvolver câncer na mama oposta caso sejam portadoras de mutações genéticas que as predisponham ao desenvolvimento de câncer de mama, de acordo com um estudo conduzido pelo Centro de Câncer da Mayo Clinic.

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Las mujeres con cáncer en una mama pueden tener un mayor riesgo de presentar cáncer en la otra mama si son portadoras de cambios genéticos específicos que las predisponen a desarrollar cáncer de mama, de acuerdo con un estudio liderado por el Centro Oncológico Integral de Mayo Clinic.

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Wistar scientists have identified a gene signature that accurately predicts the functioning of P53 variants, important information to assessing cancer risk and optimizing choices for cancer therapeutics.

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This research suggests that BAF and related proteins could be therapeutic targets to prevent these viruses from spreading and leading to cancers, such as Kaposi sarcoma, non-Hodgkin lymphoma, Hodgkin lymphoma, multicentric Castleman disease, nasopharyngeal carcinoma, and gastric cancer.

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A study from researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Cell Biology, details a previously unexplained type of cell death called disulfidptosis that could open the door for novel cancer therapeutic strategies.

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In a new study led by Children’s Hospital of Philadelphia (CHOP) and Nemours Children’s Health, researchers have overcome the obstacle of scale by analyzing electronic health record data from PEDSnet, a national multicenter pediatric network, to identify a large cohort of children with CKD, evaluate CKD progression, and examine clinical risk factors for kidney function decline. The findings were published in the Clinical Journal of the American Society of Nephrology.

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UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery. The findings, reported in Cell, could lead to new ways of controlling gene regulation and may one day lead to new treatments for a broad array of diseases.

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Adults ages 50 and older who lived near dense fast food and unhealthy food environments known as “food swamps” had a higher risk of stroke compared to those who lived in areas with fewer retail and fast food choices, according to preliminary research to be presented at the American Stroke Association’s International Stroke Conference 2023.

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Florida State University has been awarded a $72.7 million grant from the National Institutes of Health (NIH) to redesign and improve HIV prevention and care interventions in adolescents and young adults in the United States. Under the grant, which will be dispersed over the course of seven years, FSU will serve as the Scientific Leadership Center (SLC) for the Adolescent Medicine Trials Network for HIV Interventions.

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St. Jude scientists added a small physical structure called an anchor domain to the CAR molecule. The anchor domain connects the CAR to the internal infrastructure of the immune cell. It augments and helps organize the immune synapse

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American Society for Biochemistry and Molecular Biology endorses NIH moves toward disability inclusion and calls for broad federal effort to support scientists with disabilities

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Cedars-Sinai Cancer investigators have developed a new nanotechnology-based test that can detect and profile prostate cancers—even in microscopic amounts.

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Investigadores y colaboradores de Mayo Clinic han descubierto hallazgos clínicos clave que pueden ayudar a los médicos clínicos a reconocer causas que podrían tratar la demencia rápidamente progresiva en pacientes que, de lo contrario, podrían recibir un diagnóstico de enfermedad de Creutzfeldt-Jakob. Su estudio se publicó en la versión en línea de Neurology Clinical Practice, la revista médica oficial de la Academia Americana de Neurología.

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Os pesquisadores e colaboradores da Mayo Clinic identificaram achados clínicos importantes que podem ajudar os médicos a reconhecer pacientes com causas potencialmente tratáveis de demência rapidamente progressiva e que seriam diagnosticados erroneamente com a doença de Creutzfeldt-Jakob. O estudo foi publicado on-line na Neurology Clinical Practice, uma revista médica oficial da American Academy of Neurology.

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Implementing financial coaching for parents of infants in a pediatric primary care setting reduced missed well-child care visit rates by half and significantly improved receipt of vaccinations at a timely age, according to a new community-partnered pilot study led by UCLA researchers.

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A new study by UC Davis MIND Institute researchers finds that changes in the IQ level of autistic youth may help predict their developmental path as adolescents.

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Research findings published in Frontiers in Immunology show that cancer immunotherapy does not interfere with COVID-19 immunity in previously vaccinated patients. These findings support recommending vaccination for patients with cancer, including those receiving systemic therapies, say Saint Louis University scientists.

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Biomedical engineer Yuan Yang has received nearly $2 million in funding from the National Institutes of Health and the American Heart Association to examine the impact of strokes and the movement impairments stroke patients suffer.

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UNC-Chapel Hill scientists and colleagues provide indirect evidence for the existence of a distinct latent reservoir of CD4+ T cells in the central nervous system, by analyzing rebound virus in the cerebral spinal fluid during the period when people had just stopped taking ART.

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A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.

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Using focused-ultrasound-mediated liquid biopsy in a mouse model released more tau proteins and another biomarker into the blood than without the intervention. This noninvasive method could facilitate diagnosis of neurodegenerative disorders, according to research from Washington University in St. Louis.

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UC San Diego scientists developed an artificial intelligence tool that could accelerate the development of new high affinity antibody drugs.

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Using a crowdsourcing framework utilized over the past five years, Juliet Iwelunmor, Ph.D., professor of global health and behavioral science and health education at Saint Louis University’s College for Public Health and Social Justice, is taking what she learned from empowering youth in Nigeria to identify young people in the United States who aim to become the next generation of HIV researchers, leaders and innovators in the field.

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A new UC Davis study reveals the interaction between tumor microbiome and the immune system may be the secret to improving outcomes for sarcoma patients.

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Inmazeb (REGN-EB3), developed by Regeneron, is a three-antibody cocktail designed to target the Ebola virus glycoprotein. The drug was first approved for clinical use in October 2020, but its exact mechanism of action has remained unclear.

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UT Southwestern physician-scientist Hesham Sadek, M.D., Ph.D., has received the prestigious National Institutes of Health (NIH) Outstanding Investigator Award to support his ongoing research into mechanisms behind heart regeneration that could lead to treatments for heart failure.

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Irvine, Calif., Jan. 30, 2023 — Combating Alzheimer’s and other neurodegenerative diseases by inserting healthy new immune cells into the brain has taken a leap toward reality. Neuroscientists at the University of California, Irvine and the University of Pennsylvania have found a way to safely thwart the brain’s resistance to them, vaulting a key hurdle in the quest.

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In an academic-industrial collaboration, Mayo Clinic is assessing in a clinical trial a new radiotracer in pancreatic cancer imaging.

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Clemson University researchers have identified an enzyme and its products in humans that reduce diet-induced obesity.

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Vinegar flies use pheromones to ensure that they court and mate with members of the same species. As new fly species split off from a common ancestor, but continue to share the same environment, they need a way to rapidly diversify their pheromones to suppress inter-species mating. New research identifies a link between the genetic instructions for the production and perception of sex pheromones.

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Johns Hopkins Medicine investigators say their research indicates a new combination of drugs is needed to find an effective treatment for TB meningitis due to multidrug-resistant (MDR) strains

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monoclonal antibody treatment was found to be safe, well tolerated, and effective in protecting against malaria in a small group of healthy volunteers who were exposed to malaria in a challenge study, according to new research published in The Lancet Infectious Diseases by researchers at the University of Maryland School of Medicine (UMSOM).

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A new study that analyzed the tumor microenvironment of pancreatic cancer revealed the cause of tumor cell resistance to immunotherapy and resulted in new treatment strategies.

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A new clinical and preclinical study from UCLA Jonsson Comprehensive Cancer Center identifies the DNA roots of resistance to targeted cancer therapy, providing a possible strategy to address a vexing issue in cancer therapeutics. Results are published online ahead of print in Cancer Discovery, a journal of the American Association for Cancer Research.

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In the journal Gastroenterology, researchers from University Hospitals and Case Western Reserve University School of Medicine in Cleveland publish a review of studies about the microbiome's role in disease and discuss data from clinical trials involving individuals with digestive issues and Crohn's disease treated with a probiotic formulation. Results showed the formulation reduced severity and frequency of overall GI symptoms and positively modulated specific symptoms.

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People with diabetes who experience periods of low blood sugar — a common occurrence in those new to blood sugar management — are more likely to have worsening diabetic eye disease. Now, researchers at Johns Hopkins Medicine say they have linked such low blood sugar levels with a molecular pathway that is turned on in oxygen-starved cells in the eye.

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Scientists have developed a tiny mechanical probe that can measure the inherent stiffness of cells and tissues as well as the internal forces the cells generate and exert on one another.

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In-training and early career neurosurgeons who were awarded Neurosurgery Research & Education Foundation (NREF) funding have significant success in acquiring subsequent grant support, research productivity and achievements of academic rank, according to a study done by the NREF, which examined the impact of NREF grants from 2000-2015.

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Mount Sinai researchers have been awarded $12 million over five years by the National Institutes of Health to create a center to elucidate novel causes of, and contributing factors to, food allergies and atopic dermatitis. The Systems Biology of Early Atopy (SunBEAm) Analysis and Bioinformatics Center intends to develop a better understanding of allergy development. The center will apply systems biology to identify early-life markers of risk for food allergies and atopic dermatitis (also known as eczema), as well as biological pathways underlying these common conditions, through the profiling and analysis of longitudinal multi-omics data from a multi-center pre-birth cohort of 2,500 children.

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Researchers at the University of Miami Miller School of Medicine were awarded a $2.9 million grant by the National Institutes of Health (NIH) to spend the next five years collecting and analyzing the genetic data of more than 3,000 Hispanic individuals, to better understand IBD in that community.

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People with early cardiovascular disease may be more likely to have memory and thinking problems and worse brain health in middle age, according to new research published in the January 25, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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For the first time, researchers at UC San Diego have created an atomic-level computer model of the H1N1 virus that reveals new vulnerabilities, suggesting possible strategies for the design of future vaccines and antivirals against influenza.

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The Wildlife Conservation Society (WCS) released an image of scientists taking a swab from a straw-colored fruit bat (Eidolon helvum) to test it for zoonotic diseases such as the Ebola virus.

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New research shows that mental health organizations may systematically transmit bias and racism through common bureaucratic processes and, in some cases, through staff merely doing their job.

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UCSF researchers systematically tested CSF1R inhibition using multiple drug analogs at several time points in transgenic mice developing spontaneous tauopathy. The researchers demonstrated a reduction of tau pathology in multiple dosing schemes without complete microglial ablation.