A groundbreaking Loyola Medicine study suggests that a simple 15-minute electrocardiogram could help a physician determine whether a patient has major depression or bipolar disorder.
PHILADELPHIA—Anil K. Rustgi, MD, chief of the division of Gastroenterology and T. Grier Miller Professor of Medicine and Genetics, and Hongzhe Li, PhD, a professor of biostatistics in Biostatistics and Epidemiology, both at the Perelman School of Medicine at the University of Pennsylvania, have been named fellows of the American Association for the Advancement of Science, the world’s largest general scientific society and publisher of the journal Science.
An investigator at Children’s Hospital Los Angeles, has been awarded $1.5 million by the National Institute of Diabetes and Digestive and Kidney Diseases of the NIH for the study of tumor necrosis factor (TNF) and its role in inflammatory bowel disease (IBD).
Four Rutgers University professors have been named fellows of the American Association for the Advancement of Science (AAAS), an honor bestowed by their peers for scientifically or socially distinguished efforts to advance human knowledge. The honorees, representing Rutgers University-New Brunswick and Rutgers Biomedical and Health Sciences (RBHS), will be presented with official certificates and gold and blue rosette pins – the colors representing science and engineering – at the Feb. 17 AAAS Annual Meeting in Austin, Texas.
A large multicenter study found that patients with cystic fibrosis (CF) – who tend to develop chronic lung infections – had more good and bad bacteria in their lungs compared to controls. The study used bronchoalveolar lavage, in which a bronchoscope is directed into the lung to directly collect lung secretions, and also found less diversity of bacteria in the lungs of CF patients who were older and had more lung disease or inflammation. Results, published in the European Respiratory Journal, provide a basis for future treatment studies.
Gold nanoparticles could help make drugs act more quickly and effectively, according to new research conducted at Binghamton University, State University of New York.
https://www.ncbi.nlm.nih.gov/pubmed/29078267
A PCR-based approach to a frontier of the human genome -- the centromere -- could speed discovery in chromosome-based diseases and birth defects.
Following the paths of radicals and finding many damaged residues because of incredibly accurate, fast and sensitive mass spectrometry, three Washington University scientists studied the great granddaddy of all photosynthetic organisms — a strain of cyanobacteria — to develop the first experimental map of that organism’s water world.
The immune cells that are trained to fight off the body’s invaders can become defective. It’s what allows cancer to develop. So most research has targeted these co-called effector T-cells. But a new study takes a step back and considers: What if the problem isn’t with the effector T-cells but starts higher up the cellular chain?
As a young scientist, British researcher David Peters was focused on brain aneurysms as researched through the lens of high-throughput genomics. But when his wife became pregnant with the first of their two children, his world – both as a husband and a scientist – dramatically changed course.
Mount Sinai researchers identify new protein in a common subtype of breast cancer which can potentially offer more effective therapies for the future
Biologists at Berkeley Lab and UC Berkeley used cryo-EM to resolve the structure of a ring of proteins used by the immune system to summon support when under attack, providing new insight into potential strategies for protection from pathogens. The researchers captured the high-resolution image of a protein ring, called an inflammasome, as it was bound to flagellin, a protein from the whiplike tail used by bacteria to propel themselves forward.
Scientists have identified a set of biomarkers that indicate which patients infected with the Ebola virus are most at risk of dying from the disease. The results come from one of the most in-depth studies ever of blood samples from patients with Ebola.
Never-before-seen images of mouse immune system proteins and bacterial bits reveal an inspection strategy that identifies pathogens.
Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs. The computer program, called DrugPredict, matches existing data about FDA-approved drugs to diseases, and predicts potential drug efficacy. In a recent study published in Oncogene, the researchers successfully translated DrugPredict results into the laboratory, and showed common pain medications—like aspirin—can kill patient-derived epithelial ovarian cancer cells.
In a comprehensive and complex molecular study of blood samples from Ebola patients in Sierra Leone, published today (Nov. 16, 2017) in Cell Host and Microbe, a scientific team led by the University of Wisconsin–Madison has identified signatures of Ebola virus disease that may aid in future treatment efforts.
The research shows that a range of compounds can deliver pain-blocking potency without affecting respiration.
Seattle Children’s has opened the first chimeric antigen receptor (CAR) T-cell immunotherapy trial in the U.S. for children and young adults with relapsed or refractory CD19- and CD22-positive acute lymphoblastic leukemia (ALL) that will simultaneously attack two targets on cancer cells.
By focusing on genetic variations within a primary tumor, differences between the primary and a metastatic tumor, and additional diversity from tumor DNA in the blood stream, physicians can make better treatment choices for patients with gastric and esophageal adenocarcinoma. This study challenges current guidelines and supports evaluation of metastatic lesions and circulating tumor DNA.”
By binding photosensitive dyes to common plastic membranes and adding water, chemists at the University of California, Irvine have made a new type of solar power generator. The device is similar to familiar silicon photovoltaic cells but differs in a fundamental way: Instead of being produced via electrons, its electricity comes from the motion of ions.
After boys and young men with Duchenne muscular dystrophy received cardiac progenitor cell infusions, medical tests indicated that the patients’ hearts appeared improved, results from a new study show. Patients in the study also scored higher on arm strength tests after receiving the cell infusions.
Seattle Children’s today launched a $1 billion initiative, It Starts With Yes: The Campaign for Seattle Children’s, with a bold vision: to transform children’s health. It Starts With Yes is the largest campaign in Seattle Children’s 110-year history.
A research team at The University of Texas at El Paso is one step closer to developing an effective human vaccine for cutaneous leishmaniasis, a tropical disease found in Texas and Oklahoma, and affecting some U.S. troops stationed in Afghanistan and Iraq.
Seven years ago Cincinnati Children’s scientists first used pluripotent stem cells to mimic natural human development and grow working human intestine in a lab. Today medical center doctors can bioengineer the gastrointestinal tissues of sick children to find clues about a child’s disease and how to treat it. Cincinnati Children’s is building on this early research advancement in personalized medicine by launching the Center for Stem Cell and Organoid Medicine (CuSTOM).
In a study published in Stem Cell Reports, Rui Zhao and colleagues have partly solved a long-unanswered basic question about stem cells — why are pluripotent stem cells that have mutations to block the production of microRNAs unable to differentiate?
Brahim Chaqour, PhD, professor of cell biology and ophthalmology at SUNY Downstate Medical Center, has received two awards to support research into treatment of currently incurable vision-threatening diseases. The new awards, totaling $2,008,973, are from the National Eye Institute of the National Institutes of Health (NIH).
New research from the University of Maryland School of Medicine suggests that the system for choosing transplant recipients in chronic obstructive pulmonary disease (COPD) may underestimate how long a person might survive without a lung transplant and therefore, may mislead clinicians.
A new UC San Francisco–led study challenges the dogma in oncology that most cancers are caused by one dominant “driver” mutation that can be treated in isolation with a single targeted drug.
Primary liver cancer is now the second leading cause of cancer-related death worldwide, and its incidences and mortality are increasing rapidly in the United Stated. In late stages of the malignancy, there are no effective treatments or drugs. However, an unexpected finding made by a team of University of California San Diego School of Medicine researchers sheds light on the development of a new strategy for prevention of liver cancer.
Cornell researchers have taken a major step toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it metastasizes?
Results from two early clinical trials show that it may be possible to use human embryonic stem cells as treatment for the dry form of macular degeneration, according to presentations given today at AAO 2017, the 121st Annual Meeting of the American Academy of Ophthalmology.
The American Society for Cell Biology (ASCB) is pleased to announce the 2017 cohort of ASCB Fellows. The honor of being named an ASCB Fellow is bestowed to ASCB members by their peers. Fellows are recognized for their meritorious efforts to advance cell biology and its applications and for their service to ASCB.
In experiments with mice that have a rodent form of Marfan syndrome, Johns Hopkins researchers report that even modestly increasing stress on the animals’ hearts — at levels well-tolerated in normal mice — can initiate heart failure. The findings, described August 4 in the Journal of Clinical Investigation Insight, revealed a novel cellular pathway in heart tissue that leads to heart failure and may serve as a model for a new standard of treatment for children with this aggressive form of Marfan syndrome.
Researchers at Queen’s University Belfast together with the University of Vienna have discovered that treatment for the antibiotic resistant bacteria Klebsiella pneumoniae could lie within our bodies’ natural defences.
It takes less than one-tenth of a second — a fraction of the time previously thought — for the sense of smell to distinguish between one odor and another, new experiments in mice show.
Scientists have shown that a protein called membralin is critical for keeping Alzheimer’s disease pathology in check. The study, published in Nature Communications, shows that membralin regulates the cell’s machinery for producing beta-amyloid (or amyloid beta, Aβ), the protein that causes neurons to die in Alzheimer’s disease.
In 2012, LJI researcher Toshiaki Kawakami, M.D., Ph.D., reported that a small protein aptly named histamine-releasing factor (HRF) played a pro-inflammatory role in asthma. The current paper reports a novel biochemical mechanism governing HRF activity, paves the way for blood tests to predict which patients will respond to allergy therapy, and strongly supports the idea that drugs designed to block HRF could prevent food allergy attacks.
UT Southwestern’s O’Donnell Brain Institute will help in an international effort to map and characterize all the cells in the human body, an ambitious project aimed at gaining insight into how cellular changes can cause disease.
Wistar researchers discovered a novel form of crosstalk among tumor cells and other cell types in the tumor microenvironment, elucidating the mechanism of action of an immunotherapeutic strategy that inhibits tumor-associated macrophages (TAMs) and instructing a more effective use of this therapeutic approach. This work was published online in Cancer Cell.
A novel computational method allows researchers to parse how multiple organs contribute to a disease over time, giving a more holistic view of disease and potentially revealing new avenues for intervention.
Although estimates vary, scientists believe that 50 to 64 percent of the risk of alcohol use disorders (AUDs) is inherited. One way to identify this risk is through a person’s subjective response to alcohol. This study investigated the effects of two single-nucleotide polymorphisms (SNPs) or changes in DNA sequence called rs279858 (in the GABRA2 gene) and rs2832407 (in the GRIK1 gene) – previously linked to AUD risk – on individuals’ subjective responses to intravenously administered alcohol.
Ludwig Cancer Research has released the scope of its participation at this year’s Annual Meeting and Education Day of the Society for Neuro-Oncology in San Francisco, California, November 16-19.
A research team has identified the pathological mechanism for a certain type of autism and intellectual disability by creating a genetically modified mouse. They are hopeful it could eventually lead to a therapeutic fix.
Researchers at SBP have identified a peptide that could lead to the early detection of Alzheimer’s disease (AD). The discovery, published in Nature Communications, may also provide a means of homing drugs to diseased areas of the brain to treat AD, Parkinson’s disease, as well as glioblastoma, brain injuries and stroke.
Editor's Highlights include papers on aryl hydrocarbon receptor activation and neutrophil function; transcriptomic analysis of TCE and PCE in the liver and kidney; functional genomics of TCE metabolites genotoxicity; and increased aflatoxin b1 damage in pregnant mice.
Depletion of a fatty molecule in human blood propels malaria parasites to stop replicating and causing illness in people and instead to jump ship to mosquitoes to continue the transmission cycle, according to a new study by an international research team.
Inside cells, protein “motors” act like trucks on tiny cellular highways to deliver life-sustaining cargoes. Now a team led by Rutgers University–New Brunswick researchers has discovered how cells deploy enzymes to place traffic control and “roadway under construction” signs along cellular highways.
UC Santa Cruz’s genomics investigators have built a research powerhouse in sequencing, storing, cataloging, assembling, validating, and analyzing huge volumes of genomic data in their mission to use genomics to positively impact health, nature, and society. The UC Santa Cruz Genomics Institute is leading the effort to establish global standards to capture and share genomic data fairly and responsibly. Without a medical school and hospital, UCSC has become a neutral, trusted genomics research partner to medical institutions and universities around the world, contributing databases and research, and improving human health. This is made possible by its world-class computational abilities.
New findings from University of Kentucky faculty published in Scientific Reports reveals a novel cell signaling interaction that may prevent a key step in lung cancer progression.
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