Exploring the Mystery of How Enzymes Work via Simulations
American Institute of Physics (AIP)There is broad scientific interest in understanding the origin of the catalytic power of enzymes on a molecular level. While hypotheses have been put forward using experimental and computational approaches, they must be examined critically. In the Journal of Chemical Physics, researchers present a critical review of the dynamical concept—time-dependent coupling between protein conformational motions and chemical reactions—that explores all reasonable definitions of what does and does not qualify as a dynamical effect.