A Florida State University researcher has received a National Institutes of Health grant to investigate how daily low oxygen exposure affects weight, body composition and metabolic health.
Whether consuming cocoa, known to be packed with powerful antioxidants that protect our cells from damage, helps us age better, is a question scientists want to definitively answer.
Using a virus that grows in black-eyed pea plants, researchers developed a new therapy that could keep metastatic cancers from spreading to the lungs, as well as treat established tumors in the lungs.
A family of proteins best known for their role in diminishing HIV infectivity may have the goods to outwit other emerging and re-emerging viruses, scientists have found.
A new study from researchers at The University of Texas MD Anderson Cancer Center showed that stereotactic ablative radiotherapy (SABR) was as effective as surgery at providing long-term benefits to patients with operable early-stage non-small cell lung cancer (NSCLC) and generated minimal side effects. The study is the first of its kind to compare long-term results of SABR against surgical treatment in patients with operable early-stage NSCLC.
A five-year, $61.7 million grant to the Vagelos College of Physicians and Surgeons will help medical researchers speed the application of scientific discoveries, so that new treatments can be delivered to patients faster.
A new study by researchers at University of Illinois Chicago suggests that when the protein optineurin, or OPTN, is present in cells it restricts the spread of HSV-1, the herpes simplex virus type 1.In a “first of its kind” study, researchers also found a potential direct connection between neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), glaucoma, and the herpesvirus.
Scientists have created the precision-guided sterile insect technique, a new CRISPR-based technology to control Aedes aegypti, the mosquito species responsible for spreading wide-ranging diseases including dengue fever, chikungunya and Zika.
Washington University School of Medicine in St. Louis has received a $7 million grant from the National Institutes of Health (NIH) to help lead national efforts to investigate how variations in the human genome sequence affect how the genome functions. The university will serve as the data and administrative coordinating center for the Impact of Genomic Variation on Function (IGVF) Consortium.
Johns Hopkins Medicine researchers report that food science principles have helped them determine how unusual droplets within cells stay organized and avoid dissolving into the rest of the cell’s gelatinous interior.
A new study in animal models shows that a cancer tumor alone can lead to cardiac damage, and suggests the culprits are free radicals interacting with cells in the heart. Adding antioxidants to food consumed by fruit flies with tumors reversed the damage to their hearts.
About 300,000 to 400,000 fetuses per year from mothers with diabetes develop neural tube defects—when the tissue that eventually forms the brain and spinal cord fails to form properly—which can lead to miscarriage or profound disability.
Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different “program” that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.
Equipped with a color 3D camera, an inertial measurement sensor, and its own on-board computer, a newly improved robotic cane could offer blind and visually impaired users a new way to navigate indoors.
Researchers studying the enzyme DHPS have determined that blocking its activity in mouse macrophages leads to a reduction in proteins that drive inflammation during obesity, leading to improved glycemic control.
A new study from scientists at the UCLA Jonsson Comprehensive Cancer Center found that emerging drugs that activate the protein STING, a well-established regulator of immune cell activation, substantially alter the activity of metabolic pathways responsible for generating the nucleotide building blocks for DNA.
A retrospective analysis of large datasets of biomarkers from tumors and healthy tissue by researchers at the Johns Hopkins Kimmel Cancer Center Convergence Institute suggests that older cancer patients could benefit as much as younger patients from cancer immunotherapies.
Researchers at the Icahn School of Medicine at Mount Sinai found that a tool commonly used in research for evaluating a person’s genetic risk for a disease, called a polygenic risk score, was no better at predicting the outcome of a schizophrenia patient’s disease over time than written reports. The results raise important questions about the use of polygenic risk scores in real-world, clinical situations, and also suggest that a doctor’s written report may be an untapped source of predictive information.
Huntsman Cancer Institute melanoma researchers have generated the first “atlas” of human melanocytes located in the body.
Losing weight and treating excess levels of fat in the blood may help prevent lung disease in firefighters exposed to dangerous levels of fine particles from fire, smoke, and toxic chemicals on Sept. 11, 2001, a new study shows.
St. Jude Children’s Research Hospital scientists detail how inflammasomes act as integral components of mega-cell death complexes called PANoptosomes for host defense in live viral and bacterial infections.
Two studies led by Washington University School of Medicine in St. Louis describe the potential of liquid biopsies to identify and track tumor growth in two very different cancers: bladder cancer and peripheral nerve tumors.
Lab studies reveal protein HSP27’s role in blood vessel leakage, opening the possibility that therapeutically dialing its activity up or down might stabilize patients with sepsis.
A rare but serious inflammatory condition that affects children who contract COVID-19 produces a distinctive pattern of biomarkers that may help physicians predict disease severity and also aid researchers in developing new treatments, according to a study led by Cedars-Sinai.
Two National Institute of Health (NIH) grants totaling over $1.3 million will enable research into antibody-mediated drug delivery technology for the treatment of cancer and autoimmune disorders. L. Nathan Tumey, assistant professor of pharmaceutical sciences, is the Principal Investigator on both grants — $1.2 million from the National Institute of General Medical Sciences and $150,000 from the National Institute of Allergy and Infectious Diseases.
The University of Kentucky Center for Clinical and Translational Science has received a $23.5 million, four-year award from the National Center for Advancing Translational Sciences at the National Institutes of Health. This is the third time the CCTS has successfully competed for the prestigious Clinical and Translational Award, with continuous funding since 2011 totaling $65.4 million in research dollars.
In an effort to understand how these states influence the brain’s decision-making processes, scientists at the Icahn School of Medicine at Mount Sinai analyzed the data from a previous pre-clinical study. They found that two of the brain’s decision-making centers contain neurons that may exclusively monitor the body’s internal dynamics. Furthermore, a heightened state of arousal appeared to rewire one of the centers by turning some decision-making neurons into internal state monitors.
Cutting 20% of sugar from packaged foods and 40% from beverages could prevent 2.48 million cardiovascular disease events
Researchers identified 579 locations in the human genome associated with a predisposition to self-regulation-related behaviors, such as addiction. With data from 1.5 million people of European descent, the effort is one of the largest genome-wide association studies to date.
Department of Rehabilitation and Human Performance will lead Mount Sinai in national clinical trial
A Wistar study shows the tumor suppressor Parkin, whose levels are reduced in different cancer types, causes acute metabolic and oxidative stress, suppresses mitochondrial trafficking, and blocks tumor cell movement, reducing primary and metastatic tumor growth.
The United States’ longest-running NIH-sponsored musculoskeletal research center will receive $4M to continue its studies of everything from ligament tears to osteoarthritis
UC San Diego researchers identify the mutational drivers for gastrointestinal stroma tumors in the stomach and find a potential drug to treat a subset of GIST tumors afflicting the young.
Researchers at Albert Einstein College of Medicine and the City University of New York Graduate School of Public Health and Health Policy (CUNYSPH) have been awarded a five-year, $14.5 million grant from the National Institutes of Health (NIH) to continue leading and expand their research on HIV treatment and care in five Central African nations.
Anjana Bhat, associate professor in the University of Delaware’s Department of Physical Therapy, has been awarded a research project (R01) grant through the National Institutes of Health for the next three years.
Rutgers School of Public Health assistant professor, Stephanie Shiau, has received a Career Development Award from the National Institute on Drug Abuse, part of the National Institutes of Health, to study the implications of opioid prescription use among older adults living with HIV.
Cedars-Sinai Cancer researchers have discovered that intestinal microorganisms help regulate anti-tumor immune responses to radiation treatments, and that fungi and bacteria have opposing effects on those responses.
Among adolescents ages 10 to 14 in the U.S, the overall rate of drug use remained relatively stable in the first six months of the COVID-19 pandemic. However, one change was a decreased use of alcohol, but an increased use of nicotine and misuse of prescription drugs.
The highest-ever resolution imaging of an infectious prion provides the first atomic-level data of how these abnormal proteins are assembled to cause fatal neurodegenerative diseases in people and animals—and how they can be potentially targeted by new therapies.
DALLAS – Aug. 20, 2021 – A stress signal received by the heart from fat could help protect against cardiac damage induced by obesity, a new study led by UT Southwestern researchers suggests. The finding, published online in Cell Metabolism, could help explain the “obesity paradox,” a phenomenon in which obese individuals have better short- and medium-term cardiovascular disease prognoses compared with those who are lean, but with ultimately worse long-term outcomes.
A team led by Dan H. Barouch, MD, PhD, has been awarded $4.9 million in annual funding over the next five years to find a cure for HIV. Barouch was one of ten primary investigators to receive a 2021 National Institutes of Health (NIH) Martin Delaney Collaboratories for HIV Cure Research award, which aims to expedite human immunodeficiency virus (HIV) cure research by bringing together research partners in academia, government, the private sector and the community; coordinating complex research studies, and mentoring the next generation of HIV cure researchers.
UC San Diego researchers detail how a ubiquitous signaling molecule plays a critical role in male fertility, orchestrating key steps that promote sperm motility, survival and fertilization success.
Raquel Assis, Ph.D., associate professor, College of Engineering and Computer Science, and a fellow of FAU’s Institute for Human Health and Disease Intervention, has received a five-year, $1.8 million “Maximizing Investigators’ Research Award” from the NIH. The goal of this early career award is to enhance the ability of investigators to take on ambitious scientific projects and approach problems more creatively.
New research published today in JAMA Oncology reports how two separate DNA changes appear to predict aggressive childhood leukemias when they occur in combination. This study illuminates genetic understanding of acute lymphoblastic leukemia in children with the worst outcomes.
A NIH study co-led and designed by Michigan Medicine researchers found that using convalescent plasma to treat newly infected #COVID-19 patients demonstrated no significant benefit. The trial was stopped in February 2021 due to lack of efficacy based on planned interim analysis
DALLAS – Aug. 19, 2021 – A gene called Npas4, already known to play a key role in balancing excitatory and inhibitory inputs in brain cells, appears to also be a master timekeeper for the brain’s circadian clock, new research led by UT Southwestern scientists suggests. The finding, published online today in Neuron, broadens understanding of the circadian clock’s molecular mechanisms, which could eventually lead to new treatments for managing challenges such as jet lag, shift work, and sleep disorders.
It’s long been believed that advancing age leads to broad declines in our mental abilities. Now new research from Georgetown University Medical Center offers surprisingly good news by countering this view.
New visualizations of SARS-CoV-2 have allowed researchers to discover how the virus enters and infects healthy human cells. They found that glycan sugar molecules act as infection “gates” to our cell’s receptors.
Study hints at long-term health and financial impacts of even short hospitalizations for COVID-19.
Only 21 percent of patients with severe pneumonia caused by SARS-CoV-2 (the virus that causes COVID-19) have a documented bacterial superinfection at the time of intubation, resulting in potential overuse of antibiotics, according to new research published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.
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