Brain cell dysfunction in low oxygen is, surprisingly, caused by the very same responder system that is intended to be protective, according to a new published study by a team of researchers at the Case Western Reserve University School of Medicine.
Babies born with a faulty maternal copy of the UBE3A gene will develop a severe neurodevelopmental disorder with no cure and limited treatments. Now, scientists show that gene editing/gene therapy techniques can be used to restore UBE3A in human neuron cultures and treat deficits in an animal model.
A breakthrough study, led by researchers from the University of California, Irvine, results in the restoration of retinal and visual functions of mice models suffering from inherited retinal disease.
Like a cold front that moves in, setting the stage for severe weather, coronavirus infection triggers showers of infection-fighting immune molecules - showers that sometimes escalate into a chaotic immune response known as a cytokine storm.
Instead of using synthetic materials, Penn Medicine study shows magnets could be used to arrange cells to grow new tissues
Older people who report greater levels of social engagement have more robust gray matter in regions of the brain relevant in dementia, according to new research. The findings matter during the COVID-19 pandemic.
The National Institutes of Health has launched an adaptive Phase 3 clinical trial to evaluate the safety and efficacy of three immune modulator drugs in hospitalized adults with COVID-19.
A team of researchers from UC San Diego, UCLA and the University of South Carolina has demonstrated how membrane-formation takes place in water from natural alkaline sources like soda lakes and hydrothermal oceanic vents.
A team led by Penn scientists produced a detailed picture of fuel and nutrient use by the human heart. The study was the first of its kind, involving the simultaneous sampling of blood from different parts of the circulatory system in dozens of human participants, in order to record the levels of related molecules going into and coming out of the beating heart.
A high-tech imaging study to understand how brain connectivity patterns change after deep brain stimulation in patients suffering from essential tremor has been launched at The University of Texas Health Science Center at Houston (UTHealth).
A $5 million National Institutes of Health grant awarded to the New Jersey Alliance for Clinical and Translational Science (NJ ACTS) will launch outreach campaigns and expand access to COVID-19 testing for underserved and vulnerable communities in New Jersey.
DALLAS – Oct.15, 2020 – When a child has a rare blood disorder, clinicians can struggle to find the best diagnostic and treatment methods. New research led by UT Southwestern shows the effectiveness of a treatment for aplastic anemia and reveals the range of diagnosis and treatment options used by hospitals around the country for a related disease – myelodysplastic syndrome (MDS).
The five-year NIH Science Education Partnership Award program will attempt to attract the attention of high school students in economically disadvantaged communities to be prepared and motivated to pursue undergraduate degrees in engineering as well as biomedical and behavioral sciences.
Treatment with a peptide that mimics the naturally occurring protein GIV prevents immune overreaction and supports a mechanism critical for survival in mouse models of sepsis and colitis, according to a UC San Diego study.
Researchers have used insight from a comprehensive genomic analysis of neuroblastoma to learn about the process driving one of the most common childhood solid tumors.
A multidisciplinary team from Columbia Engineering, Columbia’s College of Dental Medicine and Department of Medicine, Louisiana State University, LaCell LLC, and Obatala Sciences has now bioengineered living cartilage-bone temporomandibular joint grafts, precisely matched to the recipient, both biologically and anatomically. Their new study, published today in Science Translational Medicine, builds upon a long series of their previous work on bioengineering functional cartilage and bone for regenerative medicine and tissue models of disease.
The NIH grant will enable FAU scientists to identify the gene regulation pathways activated to program immature stem-like cells of the eye lens to attain their mature form and transparent function. The research team plans to explore the genetic and cellular mechanisms controlling developmental DNA conformational changes and will identify the transcription factors needed for eye lens formation.
Diverse teams across University of California San Diego, with collaborators elsewhere, have received two 5-year grants totaling $14.3 million from the National Institutes of Health (NIH) Common Fund to continue their work as a 4D Nucleome Research Hub and Center.
With the support of a $3.7 million grant from the National Institutes of Health’s (NIH) National Heart, Lung, and Blood Institute, an academic-industrial collaboration between General Electric Research, Rensselaer Polytechnic Institute, Cleerly, and Weill Cornell Medicine will develop cutting-edge techniques for removing the appearance of blurry images — known as blooming artifacts — from cardiac CT scans to improve the accuracy of cardiac diagnosis and prevent patients from having to undergo costly and invasive procedures.
Researchers at The Wistar Institute and collaborators from the University of Notre Dame are developing anticancer compounds targeting a pathway of the endoplasmic reticulum (ER) stress response implicated in the development of multiple myeloma (MM), chronic lymphocytic leukemia (CLL) and lymphoma.
Without directly invading the brain or nerves, the virus responsible for COVID-19 causes potentially damaging neurological injuries in about one in seven infected, a new study shows. These injuries range from temporary confusion due to low body-oxygen levels, to stroke and seizures in the most serious cases, say the study authors.
Scientists at Wake Forest School of Medicine have recorded real time changes in dopamine and serotonin levels in the human brain that are involved with perception and decision-making. These same neurochemicals also are critical to movement disorders and psychiatric conditions, including substance abuse and depression.
A grant from the National Institutes of Health will allow a Penn State College of Medicine researcher to lead a three-year, multi-institution project to create an atlas of developing mice brains.
Variations in a gene that regulates dopamine levels in the brain may influence the mobility of elderly and frail adults, according to new research.
Researchers with the Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have secured $4 million in funding from the National Institutes of Health (NIH)/National Cancer Institute (NCI) to establish an HIV-associated Malignancy Research Center focused on lung cancer in East Africa.
The National Institutes of Health has awarded a Research Project Cooperative Agreement grant to Yale Cancer Center.
The drug discovery program is focused on the assessment of hundreds of drug candidates in the CDI labs, to find the most promising potential therapies.
A new study shows that a protein — called DUSP4 — was increased in healthy brain tissue directly adjacent to epileptic tissue. The research suggests that boosting levels of DUSP4 could be a novel way of preventing or treating epilepsy.
Indica Labs, a leading provider of computational pathology software and services, are pleased to announce the formal launch of an enterprise-wide, cloud-based deployment of Indica Labs' software within the National Cancer Institute (NCI), including HALO®, HALO AI, HALO Link and HALO AP.
Oral cancer is more likely to spread in patients experiencing high levels of pain, according to a team of researchers at NYU College of Dentistry that found genetic and cellular clues as to why metastatic oral cancers are so painful.
N-acetylglucosamine, a simple sugar found in human breast milk and sold as an over-the-counter dietary supplement in the United States, promotes myelin repair in mouse models and correlates with myelination levels in multiple sclerosis patients according to a new University of California, Irvine-led study.
Caregivers learn to decipher differences in newborn cries through a combination of hard-wired instincts and on-the-job experience, a new study in rodents shows.
Sleep is vitally important for brain function and survival. Yet sleep remains one of the most poorly understood features of life. Keith Hengen, assistant professor of biology in Arts & Sciences at Washington University in St. Louis, received a three-year $1.8 million grant from the National Institutes of Health (NIH) to study the role of sleep and waking behavior in shaping the brain’s neural dynamics.
NIH, with BARDA, today announced a third round of contract awards for scale-up and manufacturing of new COVID-19 testing technologies.
A $53.6 million grant from the National Institutes of Health will aid brain scientists, including a researcher from The University of Texas Health Science Center at Houston (UTHealth), in studying the role of incidental white matter lesions, or WMLs, in dementia among diverse people with cognitive complaints.
A new international study led by scientists at La Jolla Institute for Immunology (LJI), The University of Liverpool and the University of Southampton is the first to give a detailed snapshot of how the body's CD4+ T cells respond to the SARS-CoV-2 virus. Among the findings, their work suggests that early in the illness, patients hospitalized with severe cases of COVID-19 develop a novel T cell subset that can potentially kill B cells and reduce antibody production.
Sanford Burnham Prebys Medical Discovery Institute today announced that two faculty members, Peter Adams, Ph.D., and Jerold Chun, M.D., Ph.D., have received National Institutes of Health (NIH) Director’s Transformative Research Awards. The awards, which total $8.5 million and are two of only nine granted in 2020, come from the NIH Common Fund’s High-Risk, High-Reward Program.
Computational biologist Thomas Norman, PhD, of Memorial Sloan Kettering’s (MSK) Sloan Kettering Institute (SKI) has been named one of 53 recipients of the prestigious 2020 National Institutes of Health (NIH) Director’s New Innovator Award. As part of the award, Dr. Norman will receive $1.5 million in direct costs upfront in the first year of a five-year award.
Researchers at Case Western Reserve University School of Medicine seek to optimize emerging methods of diagnosing two common neurodegenerative diseases—dementia with Lewy bodies and Parkinson’s disease dementia—which affect 1.4 million in the United States
Irvine, Calif., Oct. 6, 2020 — University of California, Irvine biomedical engineer Chang Liu is the recipient of one of nine Director’s Transformative Research Awards this year from the National Institutes of Health under its High-Risk, High-Reward Research Program, the agency announced today. Liu’s five-year, $8.4 million grant will support a project to develop a system for making antibody generation a routine and widely accessible process.
Oni Basu, PhD, an assistant professor of genetic medicine at the University of Chicago, has received the prestigious National Institutes of Health (NIH) Director’s New Innovator Award. These awards are given to exceptionally creative scientists proposing high-risk, high-impact research at all career stages.
New York University neuroscientist Christine Constantinople will examine the intricacies of our decision-making processes under a five-year, $1.5 million grant from the National Institutes of Health.
The NIH selected two researchers from the Perelman School of Medicine at the University of Pennsylvania to receive its Director’s Awards, part of the NIH Common Fund’s High-Risk, High-Reward Research Program. Brian Litt was honored with a Pioneer Award, supporting his novel neurodevice research. Gregory Corder was selected as a New Innovator Award winner for research investigating the mechanisms of chronic pain.
A coalition of 11 academic institutions and their community partners across California has received a $4.1 million grant from the NIH for a statewide community-engaged approach to addressing COVID-19 among populations that have been disproportionately affected by the pandemic.
A study finds that cancer mutations occur in distinct patterns based on the 3D structure of the genome and the underlying cause of the mutation. This helps us to understand cancer better and may lead to new treatment approaches.
A team of researchers from the University of Notre Dame, Johns Hopkins University, Ohio State University and the University of Florida has identified networks of genes that regulate the process responsible for determining whether neurons will regenerate in certain animals, such as zebrafish.
Joe Verghese, M.B.B.S., M.S., an international leader in aging and cognition research at Albert Einstein College of Medicine and Montefiore Health System, has received two grants from the National Institutes of Health totaling $13.8 million to conduct studies on pre-dementia and Alzheimer’s disease.
Researchers in the Perelman School of Medicine at the University of Pennsylvania were awarded a $3.2 million grant from the NIH to enhance research for improving heart transplant outcomes for patients. The four-year grant will fund a project exploring the use of AI-driven analysis to determine the likelihood of cardiac patients accepting or rejecting a new heart.
Patients receiving care at Moores Cancer Center at UC San Diego Health had better outcomes if they received personalized cancer therapy.
Researchers at University of California San Diego School of Medicine, in collaboration with local partners, have been awarded a $5 million grant from the National Institutes of Health (NIH) to implement a program of widespread testing for COVID-19 in San Ysidro, focused on pregnant women and children.
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