A team of Florida State University researchers from the Department of Chemistry and Biochemistry found that a natural product from the fungus Fusicoccum amygdali stabilizes a family of proteins in the cell that mediate important signaling pathways involved in the pathology of cancer and neurological diseases.
Researchers found, in mice, that changes in DNA sequence can trigger the chromosomes to misfold in a way that puts one at a heightened risk for Type 1 diabetes. The study revealed that differences in DNA sequences dramatically changed how the DNA was folded inside the nucleus, ultimately affecting the regulation of genes linked to the development Type 1 diabetes.
A Western diet containing both high fat and high sugar can induce observable skin inflammation, a study by UC Davis Health researchers has found.
It can be the bain of brain drug developers: The interface between the human brain and the bloodstream, the blood-brain-barrier, is so meticulous that animal models often fail to represent it. This improved chip represents important features more accurately.
Top-line data reported from international trial
In research published today in the journal Nature Communications, Utah-based scientists describe a novel way to treat cancers using chimeric antigen receptor (CAR) T cell therapy. Laboratory tests using mouse models and tumor cells from patients displayed promising results for this novel cellular immunotherapy for multiple myeloma and other types of blood cancer.
An anti-cancer compound developed at the University of Michigan has shown “profound” activity in mouse models against two subtypes of leukemia — representing up to 40% of patients — a U-M research team reports in the Journal of Clinical Investigation.
A diagnosis of pancreatic or colon cancer often sparks dread about the disease's likely next destination: the liver. That's because liver metastasis is a leading cause of death in these patients. A Cedars-Sinai scientific team has been awarded a $9.1 million grant by the National Cancer Institute to study this often-fatal process, with the goal of understanding how cancer spreads to the liver and finding ways to block it.
After identifying a molecular pathway that allows nonalcoholic steatohepatitis (NASH) to progress into liver cell death, University of California San Diego School of Medicine researchers were able to use these pathways to halt further liver damage.
Researchers from University of California San Diego School of Medicine have defined the most detailed list of genetic fingerprints of DNA-damaging processes that drive cancer development to date.
According to results from a Phase I/IIa trial at The University of Texas MD Anderson Cancer Center, treatment with cord blood-derived chimeric antigen receptor (CAR) natural killer (NK)-cell therapy targeting CD19 resulted in clinical responses in a majority of patients with relapsed or refractory non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL), with no major toxicities observed.
Platelet microparticles are an effective way to deliver therapeutic drugs directly to the heart following a heart attack.
Research to Prevent Blindness (RPB) celebrates the 60th anniversary of its incorporation. Watch the new video about its many sight-saving accomplishments over the past six decades.
Researchers have discovered that the brains of developing embryos provide signals to a nascent immune system that help it ward off infections and significantly improve the embryo’s ability to survive a bacterial challenge. Viable brainless frog embryos can survive for some time, but exhibit chaotic and ineffective responses.
An interdisciplinary team of researchers at the UCLA Jonsson Comprehensive Cancer Center has developed a medicated patch that can deliver immune checkpoint inhibitors and cold plasma directly to tumors to help boost the immune response and kill cancer cells.
A UCLA-led study has found that levels of six proteins in the blood can be used to gauge a person’s risk for cerebral small vessel disease, or CSVD, a brain disease that affects an estimated 11 million older adults in the U.S.
By figuring out how a common virus hides from the immune system, scientists have identified a potential vaccine to prevent sometimes deadly respiratory infections in humans.
The promise of flickering light to treat Alzheimer's takes another step forward in this new study, which reveals stark biochemical mechanisms: The 40 Hertz stimulation triggers a marked release of signaling chemicals.
Most medicines work by binding to and blocking the effect of disease-causing molecules. Now to accelerate the identification of potential new medicines, bioengineers have created a computer model that mimics the way molecules bind.
Experiences early in life have an impact on the brain’s biological and functional development, shows a new study by a team of neuroscientists. Its findings, which centered on changes in mice and rats, reveal how learning and memory abilities may vary, depending on the nature of individual experiences in early life.
Researchers at Johns Hopkins Bloomberg School of Public Health have discovered a fundamental mechanism that regulates gene activity in cells. The newly discovered mechanism targets RNA, or ribonucleic acid, a close cousin of DNA that plays an important role in cellular activity.
As the world nears poliovirus eradication, the vaccines themselves have become the greatest threat. In response to a global demand for an effective, safer-to-handle and less costly polio vaccine, scientists at the Uniformed Services University (USU) have developed a new one that could help secure a polio-free world.
Researchers developed open-source software that can classify viruses in ways that previous tools could not.
Using advanced computational methods to find working designs, researchers created six protein pairs in cells.
With $4 million in matching funds from the National Institutes of Health, the University of Washington has created a new integrated center to match biomedical discoveries with the resources needed to bring innovative products to the public and improve health.
In response to the youth vaping crisis, experts at The University of Texas Health Science Center at Houston (UTHealth) developed CATCH My Breath, a program to prevent electronic cigarette use among fifth – 12th grade students. Research published in Public Health Reports reveals the program significantly reduces the likelihood of e-cigarette use among students who complete the curriculum.
Nearly 37 percent of electronic dance music (EDM) party attendees test positive for ketamine use when samples of their hair are tested—despite only 14.6 percent disclosing that they have used the drug in the past year.
Research from the University of Kentucky’s Superfund Research Center shows that a diet high in fiber could possibly reverse the adverse effects that environmental toxins have on cardiovascular health.
A new study led by Washington University School of Medicine in St. Louis offers a genetic road map detailing the similarities and differences in immune responses to TB across three species — mice, macaques and humans. According to the researchers, the insight into the immune pathways that are activated in diverse models of TB infection will serve as a valuable tool for scientists studying and working to eradicate the disease.
People who eat or drink more foods with the antioxidant flavonol, which is found in nearly all fruits and vegetables as well as tea, may be less likely to develop Alzheimer’s dementia years later, according to a study published in the January 29, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Infectious disease scientists identified strains of group A streptococcus that are less susceptible to commonly used antibiotics, a sign that the germ causing strep throat and flesh-eating disease may be moving closer to resistance to penicillin and other related antibiotics known as beta-lactams.
Highly active adults engage in a greater variety of physical activities than do less active adults, finds a new study led by researchers at NYU Rory Meyers College of Nursing.
Researchers at UC San Diego School of Medicine, with colleagues, describe a new method for delivering neural precursor cells to spinal cord injuries in rats, reducing the risk of further injury and boosting the propagation of potentially reparative cells.
University of Wisconsin–Madison researchers have developed nanoparticles that, in the lab, can activate immune responses to cancer cells. If they are shown to work as well in the body as they do in the lab, the nanoparticles might provide an effective and more affordable way to fight cancer.
The University of Pennsylvania School of Nursing (Penn Nursing) retains its top spot for research funding for the 2019 fiscal year, among other schools of nursing, with $11.3 million in awards from the National Institutes of Health (NIH).
High levels of CO2 in the body, due to chronic respiratory disorders, may exacerbate pancreatic cancer, making it more aggressive and resistant to therapy.
A University at Buffalo-led research team is studying the details of how enzymes perform their job. The focus of the project is on understanding the molecular interactions that enable enzymes to accelerate chemical reactions.
There may be some healthy choices on restaurant menus, but most of what Americans are eating while dining out is of poor nutritional quality, according to a new study from researchers at Tufts. Disparities based on race, ethnicity, income, education also worsened over the 14-year study period.
“Bipolar disorder and schizophrenia, and many other types of mental illness, are diseases of the brain and should be treated and studied as such,” say Johns Hopkins researchers.
University of California San Diego School of Medicine researchers created a new type of brain cancer model for glioblastoma using stem cells, CRISPR and gene sequencing.
UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.
A pair of biomarkers of brain function — one that represents “listening effort,” and another that measures ability to process rapid changes in frequencies — may help to explain why a person with normal hearing may struggle to follow conversations in noisy environments, according to a new study led by Massachusetts Eye and Ear researchers. The researchers hoped the study could inform the design of next-generation clinical testing for hidden hearing loss, a condition that cannot currently be measured using standard hearing exams.
Researchers examined racial and ethnic differences in genetic testing frequency and results among diverse breast cancer patients diagnosed at age 50 or younger from January 2007 to December 2017. They found that among 1,503 diverse young breast cancer patients, less than half (46.2 percent) completed hereditary breast and ovarian cancer genetic testing. However, the percentage of women who completed genetic testing increased over time from 15.3 percent in 2007 to a peak of 72.8 percent in 2015.
Researchers at Beth Israel Deaconess Medical Center (BIDMC) have found that orthostatic hypotension was not associated with higher risk of cardiovascular events, falls, or fainting among participants in The Systolic Blood Pressure Intervention Trial. In a study published in the journal Hypertension, the scientists showed that hypertension treatment had no impact on the link between OH and cardiovascular outcomes or other adverse events.
A new study led by physician-researchers at Beth Israel Deaconess Medical Center (BIDMC) reports that the antihypertensive drug amlodipine lowered long-term gout risk compared to two other drugs commonly prescribed to lower blood pressure. The findings are published in the Journal of Hypertension.
People who eat high fiber diets are more likely to experience bloating if their high fiber diet is protein-rich as compared to carbohydrate-rich, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.
A new drug that could make it easier for doctors to diagnose multiple sclerosis (MS) in its earlier stages has been approved for its first human trials by the U.S. Food and Drug Administration (FDA).
At a glance: Research using heart cells from squirrels, mice and people identifies an evolutionary mechanism critical for heart muscle function Gene defect that affects a protein found in the heart muscle interferes with this mechanism to cause hypertrophic cardiomyopathy, a potentially fatal heart condition Imbalance in the ratio of active and inactive protein disrupts heart muscle’s ability to contract and relax normally, interferes with heart muscle’s energy consumption Treatment with a small-molecule drug restores proper contraction, energy consumption in human and rodent heart cells If affirmed in subsequent studies, the results can inform therapies that could halt disease progression, help prevent common complications, including arrhythmias and heart failure
The DNA molecule inside the nucleus of any human cell is more than six feet long. To fit into such a small space, it must fold into precise loops that also govern how genes are turned on or off. New research at Washington University School of Medicine in St. Louis indicates that "jumping genes" play a surprising role in stabilizing the 3D folding patterns of the DNA molecule inside the cell’s nucleus.
Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. In a new study, UC San Diego researchers found that opioid dependence produced permanent changes in the brains of rats.
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