Among their many extraordinary feats, some planarian flatworms reproduce by tearing off pieces of themselves to regenerate new worms. Now, researchers at the Stowers Institute for Medical Research have discovered that this process is controlled by Hox genes, a family of genes known to orchestrate important aspects of early development.
Based on preliminary findings from their research into renal and breast cancer, biochemists Archana Varadaraj and Narendiran Rajasekaran were recently awarded $469,000 by the National Institutes of Health to apply those findings to a potential treatment for Idiopathic Pulmonary Fibrosis, a serious, irreversible lung disease affecting more than 100,000 Americans.
A novel gene therapy for hemophilia A led to sustained expression of the clotting factor those patients lack, resulting in a reduction – or in some cases complete elimination – of painful and potentially life-threatening bleeding events, according to a new study led by researchers at Children’s Hospital of Philadelphia (CHOP). The results of the phase 1/2 trial, which were published today in the New England Journal of Medicine, are the first to demonstrate stable coagulation factor VIII in hemophilia A patients following gene therapy.
The University of Arkansas for Medical Sciences (UAMS) has received $18.9 million from the National Institutes of Health (NIH) to support new research and interventions that will focus on reducing cancer and cardiovascular disease disparities among people who live in rural areas and African American populations across Arkansas.
Disulfiram, a treatment for alcoholism, may cut severe SARS-CoV-2 infection, reduce likelihood of dying from COVID-19
Research in mice demonstrates how diet alters a gut microbe molecule that, in turn, prompts immune cells to downregulate inflammation.
Two genetic risk variants that are carried by nearly 40 percent of Black individuals may exacerbate the severity of both sepsis and COVID-19, a team of researchers from the University of Pennsylvania’s Perelman School of Medicine have found.
UF biological physicist Purushottam Dixit believes that artificial intelligence (AI) can let us in on cells’ conversations — and possibly help scientists introduce more targeted, effective therapies in medicine.
Now, in a study published in the journal Cell Reports Medicine, UCLA researchers report a critical step forward in the development of an “off-the-shelf” cancer immunotherapy using human stem cell-derived invariant natural killer T cells, rare but powerful immune cells that could potentially be produced in large quantities, stored for extended periods and safely used to treat a wide range of patients with various cancers.
Young adults who are diagnosed with skin, colon, and other cancer types may require different treatments than older patients receive. That is the primary conclusion of a Mount Sinai study which systematically compared the genomes of 14 different types of cancers that affected both younger and older adults.
Researchers at the National Institutes of Health have discovered a therapy that targets host cells rather than bacterial cells in treating bacterial pneumonia in rodents. The method involves white blood cells of the immune system called macrophages that eat bacteria, and a group of compounds that are naturally produced in mice and humans.
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Studies suggest that exposure to the COVID-19 pandemic has been associated with a variety of different mental health consequences including reports of depression, loneliness, and insomnia. People who are more than 65 years of age and those with underlying medical conditions such as type 2 diabetes and obesity are particularly vulnerable to negative outcomes from COVID-19. Until now, few investigations have identified and separated the mental health consequences of exposure to the COVID-19 pandemic from preexisting factors in this age group. A new prospective study of a large cohort of older adults with type 2 diabetes and overweight/obesity from across the U.S. has explored this subject with surprising results.
A new study using genetically engineered mice and human cell and tissue samples has added to evidence that higher levels of inflammatory chemicals involved in fat metabolism occur in people with amyotrophic lateral sclerosis (ALS), the neuromuscular disorder, also known as Lou Gehrig’s disease.
In a new study designed to better understand and combat these structures, Andes and his collaborators identified some of the key proteins in biofilms of the fungus Candida albicans that control both how they resist antifungal drugs and how they become dispersed throughout the body.
A new Wistar Institute study shows how key features on the surface of HIV-infected cells help the disease evade detection by the immune system.
Researchers at the University of Kentucky’s Sanders-Brown Center on Aging recently received a five-year grant renewal of their MarkVCID program from the National Institutes of Health (NIH). The award total is more than $6 million.
Combination treatment with immune checkpoint inhibitors nivolumab and ipilimumab demonstrates overall survival for patients with melanoma that has spread to the brain, according to Phase II study results published today in The Lancet Oncology by researchers from The University of Texas MD Anderson Cancer Center.
Rutgers New Jersey Medical School’s Research with a Heart is recruiting participants for the MERCK– IMPOWER studies to assess an HIV prevention oral medication on sexual minority groups.
PIEZO1, an ion channel mechanosensor found within cells, has been revealed to play a key role in regulating the speed of skin wound healing by researchers at the University of California, Irvine (UCI).
Using data generated from patients and mice with genetic mutation for the disorder Usher syndrome, researchers from the University of Maryland School of Medicine and the National Institutes of Health documented the natural history of vision impairment in patients and identified the cell mechanism behind progressive vision loss.
Exposure in utero to a drug used to prevent miscarriage can lead to an increased risk of developing cancer, according to researchers at The University of Texas Health Science Center at Houston (UTHealth Houston).
The University of Chicago and Rush University have received a $20 million, five-year grant from the National Institutes of Health (NIH) to establish a Center for Multiple Chronic Diseases Associated with Health Disparities.
St. Jude Children’s Research Hospital scientists have identified the primary target of the experimental cancer drug CX-5164, revealing a possible risk for late effects of treatment.
Leptin, a molecule produced by fat cells, appears to cancel out the effects of the estrogen-blocking therapy tamoxifen, a drug commonly used to treat and prevent breast cancers, suggests a new study led by researchers from the Johns Hopkins Kimmel Cancer Center.
A biomedical engineering professor at Binghamton University, State University of New York has received a $2.4 million grant to develop a faster, less painful way to diagnose malignant solitary pulmonary nodules (SPNs).
Professor Antonio Giordano, M.D., Ph.D., Neapolitan Oncologist, Director of the Sbarro Institute for Cancer Research at Temple University and founder of the Sbarro Health Research Organization (SHRO), met today with Congresswoman Rosa DeLauro (D-CT), Chair of the House Appropriations Committee, at the Rayburn House Office Building on Capitol Hill.
Washington University School of Medicine in St. Louis has received a $17 million grant from the National Institutes of Health (NIH) to address disparities in cancer research, treatment and outcomes in underrepresented populations. The research, funded through the National Cancer Institute’s Cancer Moonshot program, will focus on African American patients with colorectal cancer and multiple myeloma, as well as patients of any race or ethnicity with cholangiocarcinoma, a rare cancer of the bile ducts.
A new study from Washington University School of Medicine in St. Louis has identified an RNA molecule that suppresses prostate tumors. The scientists found that prostate cancers develop ways to shut down this RNA molecule to allow themselves to grow.
A safe, localized treatment for chronic inflammation in the intestinal tract will move one step closer to helping patients reduce their risk of developing colon cancer.
New findings by UT Southwestern researchers help better understand the how one of the most commonly mutated genetic drivers of cancer passes signals that cause the disease.
Researchers at the University of Maryland School of Medicine (UMSOM)’s Institute of Human Virology (IHV), a Global Virus Network (GVN) Center of Excellence, have received $6.5 million from the U.S. National Institutes of Health (NIH) to streamline big data collection in Nigeria and South Africa in addressing public health needs of the COVID-19 and HIV pandemics.
The Vanderbilt Undiagnosed Diseases Program (VUDP), which accepts patients with undiagnosed and rare diseases, will be part of a unique network of institutions dedicated to the outstanding treatment of rare disease patients and collaboration to improve standards of care, advance research and increase awareness about rare diseases in the broader medical and patient communities.
Dilated cardiomyopathy due to titin gene mutations involves both a shortage of good titin and a buildup of mutant, potentially “bad” titin
A new study led by researchers at Washington University School of Medicine in St. Louis suggests that a widely used heart failure drug named sacubitril/valsartan is no better than valsartan alone in patients with severe heart failure. The study also provides evidence that the treatment with valsartan may be slightly safer for patients with advanced heart failure.
Humans are able to think a few steps ahead in non-social situations, such as navigating a new hiking trail or planning a vacation. A Mount Sinai study now shows that we may also do this when interacting with other people.
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Researchers reporting in ACS Central Science developed a method for imaging lithium in living cells, allowing them to discover that neurons from bipolar disorder patients accumulate higher levels of lithium than healthy controls.
One of the largest studies to investigate whether Preserved Ratio Impaired Spirometry (PRISm), an understudied low lung function state, is an early predictor of co-morbidities has found it is strongly associated with an increased risk of death. The analysis, led by University of Bristol researchers and published in The Lancet Respiratory Medicine, evaluated results of lung spirometry tests in over 350,000 UK adults and followed them up over 12 years.
A research collaboration between scientists at Duke University and the University of North Carolina at Chapel Hill has identified and tested an antibody that limits the severity of infections from a variety of coronaviruses, including those that cause COVID-19 as well as the original SARS illness.
A five-year, $2.59 million grant from the National Institutes of Health will allow a psychology professor at Binghamton University, State University of New York to study the mechanisms of addiction.
Researchers have discovered neurons needed for acupuncture‘s anti-inflammatory response
In what is believed to be one of the largest studies of its kind, Johns Hopkins Medicine researchers have shown that antibody levels against SARS-CoV-2 (the COVID-19 virus) stay more durable — that is, remain higher over an extended period of time — in people who were infected by the virus and then received protection from two doses of messenger RNA (mRNA) vaccine compared with those who only got immunized.
The University of Illinois Chicago received $446 million in sponsored funding during the 2021 fiscal year, setting a record for research awards. The total amount represents an 8.6% increase over fiscal year 2020, with funding supporting over 3,500 research projects that move research to practical application.
It’s no secret that vitamin D is critical to balancing many areas of health. But from pediatric broken bones to cluster headaches, physicians and scientists at The University of Texas Health Science Center at Houston (UTHealth Houston) are still learning just how powerful the so-called “sunshine vitamin” is.
A study by UT Southwestern researchers finds that changing the biochemistry of parts of brain cells abolished the formation of amyloid beta plaques in a mouse model of Alzheimer’s disease. The finding, published in eLife, might eventually lead to treatments that prevent the memory-robbing condition in humans.
University of Utah Health scientists are on the leading edge of a pair of large studies investigating the long-term effects of COVID-19. The nationwide studies, supported by the National Institutes of Health, will attempt to answer key questions about the lingering effects of the viral disorder on pregnant individuals and their infants, as well as why some people develop post-acute sequelae of SARS-CoV-2 (PASC), including “long COVID,” and others don’t.
A new study published in Nature reports on the molecular mechanism that allows a new antibiotic drug to overcome resistance.
University of California San Diego researchers, with international colleagues, describe how energy expenditure and heat production are regulated in obesity through a previously unknown cellular pathway.
New AI model called EVE, developed by scientists at Harvard Medical School and Oxford University, outperforms other AI methods in determining whether a gene variant is benign or disease-causing. When applied to more than 36 million variants across 3,219 disease-associated proteins and genes, EVE indicated more than 256,000 human gene variants of unknown significance that should be reclassified as benign or pathogenic.
Even though young patients with metastatic colorectal cancer tend to be more fit and receive more intensive treatment than older patients, both groups survive for roughly the same amount of time, according to a new study by Dana-Farber Cancer Institute investigators.
University of California San Diego researchers describe how a pair of fundamental genetic and cellular processes — aneuploidy and unfolded protein response — are exploited by cancer cells to promote tumor survival and growth.
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