In a new study led by Yale Cancer Center, researchers demonstrate sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer.
A recommendation for more intensive blood pressure management from an influential global nonprofit that publishes clinical practice guidelines in kidney disease could, if followed, benefit nearly 25 million Americans.
Researchers at UC San Diego School of Medicine use bacteriotherapy to improve symptoms of atopic dermatitis.
A study, “Recurrent Evolution of Vertebrate Transcription Factors by Transposase Capture,” published Feb. 19 in Science, investigates how genetic elements called transposons, or “jumping genes,” are added into the mix during evolution to assemble new genes through exon shuffling.
The study in mice, “A Multifaceted Cellular Damage Repair and Prevention Pathway Promotes High Level Tolerance to Beta-lactam Antibiotics,” published Feb. 3 in the journal EMBO Reports, reveals how tolerance occurs, thanks to a system that mitigates iron toxicity in bacteria that have been exposed to penicillin.
A recent study from Rutgers Cancer Institute of New Jersey tested this possibility by analyzing tumor formation and p53 mutations in mice from different genetic backgrounds. Observations from this work may further elucidate the diversity of cancers in different Li-Fraumeni patients.
Researchers at University of California San Diego School of Medicine identified new therapeutic targets for gastrointestinal stromal tumors (GISTs) that could lead to new treatment options for patients.
The National Institutes of Health (NIH) has awarded a $2.1 million, four-year research grant to Anirban Sen Gupta at Case Western Reserve University in Cleveland, Ohio, and collaborators at the University of Michigan and University of North Carolina, to advance the design of artificial platelets that can promote and stabilize clots to stop bleeding.
DALLAS – Feb. 16, 2021 – A study that identifies how a coronavirus protein called Nsp1 blocks the activity of genes that promote viral replication provides hope for new COVID-19 treatments.
Investigators at the University of Chicago Medicine have found that women are less likely to be represented as chairs and reviewers on study sections for the National Institutes of Health (NIH), based on data from one review cycle in 2019.
Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumors, which so far have resisted the ground-breaking cancer treatment based on harnessing the body’s immune system. The discovery, reported in the journal CELL, emerged from laboratory experiments and has no immediate implications for treating patients.
Five genes may play a key part in influencing if a person will contract Lewy body dementia, and possibly dementia from Parkinson's and Alzheimer’s diseases, according to a study published in Nature Genetics Feb. 15. The genes, BIN1, TMEM175, SNCA, APOE, and GBA, were identified by a team of scientists at the National Institute of Neurological Disorders and Stroke and the National Institute on Aging, National Institutes of Health, and sequenced by The American Genome Center (TAGC), a series of state-of-the-art laboratories at the Uniformed Services University of the Health Sciences.
Researchers at the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute (Texas Biomed) may have found a new pathway to treat and control tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb). Using single-cell RNA sequencing (scRNAseq), a next-generation sequencing technology, scientists were able to further define the mechanisms that lead to TB infection and latency.
A new study from Washington University School of Medicine in St. Louis demonstrates that a liquid biopsy examining blood or urine can help gauge the effectiveness of therapy for colorectal cancer that has just begun to spread beyond the original tumor. Such a biopsy can detect lingering disease and could serve as a guide for deciding whether a patient should undergo further treatments.
Researchers have produced a groundbreaking new reference genome for the Asian malaria vector mosquito Anopheles stephensi. The achievement will help scientists engineer advanced forms of defense against malaria transmission, including targeted CRISPR and gene drive-based strategies.
The AIDS Clinical Trials Group has added rapid infusion, intramuscular injection, an inhalant, and an oral agent to its ACTIV-2 phase 2 and 3 evaluations of multiple investigational agents for treating early, symptomatic COVID-19 in a single trial for outpatient treatment.
A new brain-and-behavior study from researchers in the Perelman School of Medicine at the University of Pennsylvania clarifies how the “anomalous-is-bad” stereotype manifests, and implicates a brain region called the amygdala as one of the likely mediators of this stereotype.
Research from scientists at St. Jude Children’s Research Hospital found mutations up to two years before cancer developed, showing an opportunity for early interventions.
Subconsciously, our bodies keep time for us through an ancient means – the circadian clock. A new University of California, Irvine-led article reviews how the clock controls various aspects of homeostasis, and how organs coordinate their function over the course of a day.
Having health issues such as smoking, high cholesterol or a high body mass index (BMI) in your 20s may make you more likely to have problems with thinking and memory skills and even the brain’s ability to properly regulate its blood flow, according to a preliminary study released today that will be presented at the American Academy of Neurology's 72nd Annual Meeting in Toronto, Canada, April 25 to May 1, 2020.
A Mayo Clinic team, led by Rahmi Oklu, M.D., Ph.D., a vascular and interventional radiologist at Mayo Clinic, in collaboration with Samir Mitragotri, Ph.D., of Harvard University, report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab.
In a new study, scientists have discovered the cellular pathway that leads to osteoarthritis and have identified a commonly used anti-depressant — paroxetine — that inhibits this pathway.
Feeding method and affectionate touch patterns in depressed and non-depressed mothers and babies as well as infant’s EEG activity showed that mother-infant affectionate touch differed as a function of mood and feeding method (breastfeeding and bottle-feeding). Infants in the depressed and bottle-fed group reduced touch toward their mothers while breastfeeding had a positive effect on both mother and baby. Infants of depressed and breastfeeding mothers showed neither behavioral nor brain development dysregulation previously found in infants of depressed mothers.
Women whose household drinking water contained nitrate had babies that weighed, on average, 10 grams less than babies born to mothers where household water had no detectible nitrate, according to a new study. Even low nitrate levels — about half of the allowable level set by the U.S. Environmental Protection Agency, or EPA — caused an adverse effect.
A new study describes how cellular survival after radiation exposure depends on behavior of the protein p53 over time. In vulnerable tissues, p53 levels go up and remain high, leading to cell death. In tissues that tend to survive radiation damage, p53 levels oscillate up and down.
The sense of hearing is, quite literally, a molecular tightrope act. Turns out, it involves acrobatics as well.
Extracellular vesicles (EVs) were once thought to be waste material discarded by cells. But they have been found to play a critical role in communication between cells, carrying “cargos” of proteins, nucleic acids and other materials. Jessica Tannis of the University of Delaware has been awarded a $1.8 million National Institutes of Health (NIH) Grant to research them.
DALLAS – Feb. 5, 2021 – The COVID-19 pandemic is having a detrimental impact on substance use, mental health, and weight-related health behaviors among people with obesity, according to a new study by researchers at UT Southwestern and the UTHealth School of Public Health.
A University of Utah Health ophthalmologist is investigating how lipids known as VLC-PUFAs could be used to prevent eye disease thanks to a new way to synthesize them for research.
Treating equine donor stem cells with a growth factor called TGF-β2 may allow them to avoid “tripping” the immune response in recipients, according to new research from North Carolina State University.
Inflammation in the blood could serve as a new biomarker to help identify patients with advanced pancreatic cancer who won’t respond to the immune-stimulating drugs known as CD40 agonists, suggests a new study from researchers in the Abramson Cancer Center of the University of Pennsylvania published in JCI Insight.
Currently, there are no methods to discern the spectrum of COVID-19’s severity and predict which children with SARS-CoV-2 exposure will develop severe illness, including MIS-C. Because of this, there is an urgent need to develop a diagnostic modality to distinguish the varying phenotypes of disease and risk stratify disease.
DALLAS – Feb. 3, 2021 – Inactivating a gene in young songbirds that’s closely linked with autism spectrum disorder (ASD) prevents the birds from forming memories necessary to accurately reproduce their fathers’ songs, a new study led by UT Southwestern shows.
A $4 million subcontract grant for scientists to collect COVID-19 data from virus researchers across the country in order to develop a data coordinating center has been awarded to researchers at The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics.
In a new article published in Nature, Moffitt Cancer Center researchers demonstrate why some ovarian cancer patients evolve better than others and suggest possible approaches to improve patient outcomes.
DALLAS – Feb. 3, 2021 – Gaining more fat cells is probably not what most people want, although that might be exactly what they need to fight off diabetes and other diseases. How and where the body can add fat cells has remained a mystery – but two new studies from UT Southwestern provide answers on the way this process works.
While the number of immigrants from Arab countries to the United States has steadily increased over the past several years, family and child health research on this population remains scarce. Wayne State University College of Nursing faculty to research this disparity.
In an era of required social distancing and stressed medical resources, a virtual clinical environment that allows doctors and nurses to safely practice intubating a simulated COVID-19 patient, among other necessary procedures, could accelerate and enhance training efforts. With the support of a new $654,000 supplement grant, a team of engineers at Rensselaer Polytechnic Institute will develop an artificially intelligent agent called the Virtual Intelligent preceptor for COVID (VIVID), which will prepare teams for surgeries, to intubate patients, and to properly use personal protective gear, without increasing anyone’s risk of exposure.
A new study by researchers at University of California San Diego School of Medicine found delayed time between abnormal stool-based screening and subsequent colonoscopy was associated with an increased risk of a cancer diagnosis and death from colorectal cancer.
Chu-Young Kim, Ph.D., associate professor of chemistry and biochemistry at The University of Texas at El Paso, is helping combat the threat of superbugs – illnesses caused by drug-resistant bacteria – by returning to nature. His work is supported by a $1.2 million grant from the National Institutes of Health (NIH) to develop a biological method for producing new versions of current antibiotics that have become ineffective due to resistance
In a new study published in Blood, the official journal of the American Society of Hematology, Moffitt researchers show that immune dysregulation can directly affect the efficacy of CAR T therapy in patients with diffuse large B-cell lymphoma.
A study published today in the New England Journal of Medicine provides the most definitive evidence to date that, of the two drugs recommended for light sedation of patients receiving mechanical ventilation in the ICU, one is as effective and safe as the other.
People who start adulthood with a body mass index (BMI) in the normal range and move later in life to being overweight – but never obese – tend to live the longest, a new study suggests.
A combination of genetic mutations may explain the higher incidence of and poorer outcomes from pediatric leukemia in Hispanic and Latino children, according to Penn State College of Medicine researchers.
A surgical procedure meant to counter ulcerative colitis, an immune disease affecting the colon, may trigger a second immune system attack, a new study shows.
Women with a history of diabetes during pregnancy (gestational diabetes) are twice as likely by mid-life to develop calcium in heart arteries - a strong predictor of heart disease - even if healthy blood sugar levels were attained many years after pregnancy, according to new research published today in the American Heart Association's flagship journal Circulation.
A $1.2. million challenge grant from the Mabee Foundation brings Texas Biomedical Research Institute (Texas Biomed) closer to its goal of $10 million to fund the construction of its Nonhuman Primate Animal Facility (NHP ALFA) on its campus. The Institute is more than halfway to its goal. This project will accommodate the critical need of the Southwest National Primate Research Center (SNPRC) to provide innovative, contemporary accommodations and laboratory space for animals involved in research that aid in testing the safety and efficacy of new and improved diagnostics, therapies and vaccines at a larger scale.
Researchers have demonstrated that autism spectrum disorder (ASD) may be caused by defects in the mitochondria of brain cells.
Irvine, Calif., Feb. 1, 2021 — Researchers from the University of California, Irvine and the University of Minnesota have found that an enriched diet and companionship can reduce pain in mice with sickle cell disease by increasing serotonin. They also discovered that duloxetine, an antidepressant that boosts serotonin levels, could be an alternative to opioids in treating chronic pain.
NIH researchers and their collaborators found that inhaling unfragmented hyaluronan improves lung function in patients suffering from severe exacerbation of COPD. Hyaluronan is a sugar secreted by living tissue that acts as a scaffold for cells. Utilized as a treatment, hyaluronan decreased the number of days in the hospital.
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