A broad coalition that includes UC San Diego scientists sets commitments for field trials of powerful gene drive technology. The multidisciplinary group encourages trials that are safe, transparent and ethical.
Researchers at the National Eye Institute (NEI) report that a brain region in the superior temporal sulcus (fSTS) is crucial for processing and making decisions about visual information.
Researchers at the National Eye Institute (NEI) report that a brain region in the superior temporal sulcus (fSTS) is crucial for processing and making decisions about visual information.
Texas Biomedical Research Institute Associate Professor Corinna Ross, PhD, is a principal investigator on a $3.38 million National Institutes of Health multi-investigator grant to study “microbiome-mediated therapies for aging and healthspan” in marmosets, which are small monkeys native to South America and are becoming increasingly more important in aging and infectious disease research. Dr. Ross is partnering with University of Texas at Austin College of Pharmacy Assistant Professor Kelly Reveles, PharmD, PhD.
Researchers have identified neurons that regulate nausea-like responses in mice. When these neurons are experimentally turned on, nausea-like responses can be activated regardless of exposure to nausea-triggering substances. Without these neurons, nausea-like responses to poisons are lost.
Dr. Arum Han is leading a clinical trial-on-a-chip program to develop new drugs to help prevent preterm births with a $3.8 million grant from the National Institutes of Health’s National Center for Advancing Translational Sciences.
The FDA granted emergency use authorization today for an innovative COVID-19 viral antigen test developed with support from NIH’s RADx Initiative.
Surgical and injectable drug approaches are equally effective for treatment of bleeding inside the eye from proliferative diabetic retinopathy (PDR), according to a National Eye Institute (NEI)-supported clinical study from the DRCR Retina Network (DRCR.net).
A high-sugar diet creates a ‘double jeopardy’ impact for a protein crucial to cellular housekeeping, a new study suggests. The protein offsets cell damage from sugar, but too much sugar renders it ineffective. The results may offer insight for reducing age-related degenerative disease.
UC San Diego researchers report chemicals used for flavor in e-cigarette liquid negatively affect specialized proteins that support immune system.
UCLA scientists describe a new combination therapy that suppresses the MAPK pathway by holding cancer-driving proteins in a death grip. This combination of two small molecules has the potential to treat not only BRAF mutated melanoma but also additional aggressive subtypes of cancers, including melanoma, lung, pancreatic and colon cancers that harbor common mutations in cancer genes called RAS or NF1.
Researchers have identified a family of enzymes whose inhibition both protects neurons and encourages their growth, a pathway to potential new treatments for neurodegenerative diseases from Alzheimer’s to glaucoma.
The National Institutes of Health (NIH) awarded Professor Mahesh Mohan, D.V.M., Ph.D., and collaborators more than $3.5 million over five years to investigate the effects of cannabinoids on Human Immunodeficiency Virus (HIV) associated neurocognitive disorder (HAND). This research project aims to evaluate whether delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) alone or in combination can potentially alter DNA methylation, which is a biological process that can create a change in the expression of certain genes.
Research by a University of Georgia scientist sheds light on how two genes factor into prostate cancer cells becoming resistant to treatment, providing a potential new target for therapeutics.
The APS has been a powerful tool in the battle against the novel coronavirus, contributing more information about the structure of the virus to the International Protein Databank than any other light source in the United States.
What happens when different strains of bacteria are present in the same system? Do they co-exist? Do the strongest survive? In a microbial game of rock-paper-scissors, researchers at the University of California San Diego’s BioCircuits Institute uncovered a surprising answer.
UC San Diego researchers discovered that most people no longer produce the Siglec-12 protein, but some of those who do are at twice the risk for advanced cancer.
The COVID-19 Testing Impact Calculator is a free resource that shows how different approaches to testing and other mitigation measures, such as mask use, can curb the spread of the virus in any organization.
White blood cells are part of many immune system responses in the human body. New research shows that a specific type of those cells may cause brain cancer tissues to die – but that’s not good news, according to researchers at Penn State College of Medicine and Penn State Cancer Institute.
Researchers at Huntsman Cancer Institute at the University of Utah have identified a potential drug combination to treat uveal melanoma, a type of eye cancer. Lead author Amanda Truong, trainee in the McMahon Lab at HCI and student at the U of U, explains uveal melanoma patients frequently have changes in genes called GNAQ and GNA11.
With the support of a new grant from the National Institutes of Health, a team from Rensselaer Polytechnic Institute will examine the interactions between the brain, bone, and the gut microbiota in relation to Alzheimer’s disease. What the researchers learn could lead to new biomarker and therapeutic discoveries for both diagnosis and treatment.
The National Institutes of Health today announced 19 recommendations in six key areas of asthma diagnosis, management and treatment.
University of Pittsburgh researchers reveal a molecular basis for the deep and fundamental connection between the disruption in circadian rhythms and predisposition to substance abuse.
Removing race from clinical tools that calculate kidney function could have both advantages and disadvantages for Black patients. Newly diagnosed patients and those whose kidney disease is reclassified as more severe would have greater access to kidney specialists, faster access to the kidney-transplant waitlist. On the flipside, patients reclassified as having more severe kidney disease may become ineligible for heart, diabetes, pain control and cancer medications or may be given lower doses for these drugs. A new kidney function score would also increase the number of Black individuals ineligible to donate a kidney, potentially exacerbating organ shortages for Black people. Researchers caution that clinicians and policy makers must anticipate both the benefits and downsides of changes to the current formula to ensure that Black patients are not disadvantaged, and health disparities are not exacerbated. Scientists say the analysis should motivate researchers and cl
Scientists at St. Jude Children’s Research Hospital have shed light on the mechanisms that underlie how Aspergillus fumigatus activates the inflammasome, with implications for therapeutic development.
FAU researchers have received a two-year, $675,000 grant from the National Institute of Aging to test a mathematical model designed to optimize social and physical engagement in this population. The objective of the study is to identify strategies that will facilitate and enhance social interactions with and among older adults and counter age-related decline by pinpointing activities that will allow the social life of older adults to flourish.
November is National Diabetes Month, a time when the nation comes together to shed light on one of the leading causes of death and disability among U.S. citizens. The University of Texas at El Paso (UTEP) is joining the fight against the disease through innovative research made possible through a recent $1.2M grant by the National Institutes of Health to advance understanding of a critical diabetic heart condition.
University of California San Diego has been selected by the NIH to lead and administer an international seven-year, $28-million grant for HIV/AIDS clinical trials.
The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, has been re-funded for the next seven years by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), and collaborating NIH Institutes.
The uniquely human ability to read is the cornerstone of modern civilization, yet very little is understood about the effortless ability to derive meaning from written words. Scientists at UTHealth have now identified a crucial region in the temporal lobe, know as the mid-fusiform cortex, which appears to act as the brain’s visual dictionary.
the National Institutes of Health has renewed a Center of Biomedical Research Excellence (COBRE) grant at the University of Delaware. The COBRE research team is focused on discovery of new molecules that can be used to study and treat diseases such as breast cancer, renal cancer, Crohn’s disease, tuberculosis and Legionnaires disease.
Combining chimeric antigen receptor (CAR) T cell therapy with a PAK4 inhibitor allowed the engineered cells to punch their way through and attack solid tumors, leading to significantly enhanced survival in mice.
Using an array of tiny needles that are almost too small to see, researchers have developed a minimally invasive technique for sampling a largely unexplored human bodily fluid that could potentially provide a new source of information for routine clinical monitoring and diagnostic testing.
Defective cilia in the brain may play a role in some forms of severe schizophrenia, according to a study published in Nature Communications.
In research recently published online in Medical Image Analysis, a team of engineers demonstrated how a new algorithm they developed was able to successfully predict whether or not a COVID-19 patient would need ICU intervention. This artificial intelligence-based approach could be a valuable tool in determining a proper course of treatment for individual patients.
Researchers at The University of Texas MD Anderson Cancer Center have developed a novel targeted therapy, called POMHEX, which blocks critical metabolic pathways in cancer cells with specific genetic defects. Preclinical studies found the small-molecule enolase inhibitor to be effective in killing brain cancer cells that were missing ENO1, one of two genes encoding the enolase enzyme.
Researchers from Penn State College of Medicine are participating in a $10 million project to better understand why males and females have different survival rates with a common and deadly type of brain cancer.
Researchers at UC San Diego School of Medicine and Rady Children’s Institute for Genomic Medicine have been awarded a five-year, $8.3 million grant from the National Institutes of Health to investigate the causes of spina bifida, the most common structural defect of the central nervous system.
By disabling a function of a set of cells in mice, researchers appear to have halted the process that breaks down bone, a likely boon for osteoporosis treatment
A basic science discovery by researchers at the Johns Hopkins Bloomberg School of Public Health reveals a fundamental way cells interpret signals from their environment and may eventually pave the way for potential new therapies.
The Mediterranean (MED) diet -- rich in olive oil, fruits, vegetables, legumes, nuts and seeds -- is a recommended way to reduce the risk of heart disease, type 2 diabetes and other adverse health outcomes.
By combing the ocean for antimicrobials, scientists at the University of Wisconsin–Madison have discovered a new antifungal compound that efficiently targets multi-drug-resistant strains of deadly fungi without toxic side effects in mice.
A genetic modification in the ‘coat’ of a brain infection-causing virus may allow it to escape antibodies, according to Penn State College of Medicine researchers.
Research may lead to identifying novel therapies for cardiac patients
Tufts researchers find a key mutation causing abnormal transport of BACE1, the enzyme responsible for processing the Alzheimer’s disease-linked amyloid protein. Identification of this mutation, which is more common among African Americans with Alzheimer’s, may allow early intervention.
New research by University of Georgia scientists sheds light on why people with obstructive sleep apnea may have associated autoimmune disorders. The results could lead to better approaches to treatment and possibly new drug therapies.
Cynical hostility is a potential pathway to cardiovascular disease by preventing a healthy response to stress over time, according to a Baylor University study. Hostility generally is associated with increased risk for cardiovascular disease. But this research explored three types of hostility — emotional, behavioral and cognitive — to see whether one is more predictive of risk factors. Cynical hostility, which is cognitive, poses the greatest risk, based on stress responses.
Even before the pandemic and the presidential election, Americans reported some of the highest perceived levels of stress in the world, according to the American Psychological Association.
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